University of Oxford
Mounted-term till 30/04/2027, Full-time
The Cragg lab alongside different teams at Oxford (Wade-Martins and Magill), UCL (Kittler) and Ulm (Liss) are conducting a collaborative Wellcome Belief-funded analysis mission to discover the physiological roles of Ca2+ in regulating dopamine transmission to achieve insights into the roles of Ca2+ in Parkinson’s illness.
This mission will exploit state-of-the-art instruments to grasp the roles of Ca2+ inflow, storage and signalling inside dopamine axons in well being and illness. Our not too long ago revealed knowledge means that the roles of voltage-gated Ca2+ channels are dynamically regulated throughout striatal territories in a way that correlates with danger elements of Parkinson’s (Brimblecombe et al 2023, PMID: 37941514).
On this mission, we are going to advance understanding of the downstream coupling of Ca2+ to mitochondrial perform to raised perceive the selective vulnerability of a subset of DA neurons in Parkinson’s, and to tell druggable targets that would provide neuroprotective potential. We are actually looking for to nominate a Postdoctoral Analysis Scientist with a robust curiosity in Ca2+ biology to hitch us as a part of this thrilling collaboration.
Duties embody adapting present and creating new scientific strategies and experimental protocols; testing hypotheses and analysing scientific knowledge from quite a lot of sources, reviewing and refining working hypotheses as acceptable; contributing concepts for brand new analysis initiatives and for producing analysis revenue.
You should have a robust background in electrophysiological and/or electrochemical and/or photometry strategies, used to research neural circuits or synapses of the central nervous system. Candidates should maintain, or be near completion of, a PhD/DPhil in a related space of neurobiological analysis.
The fastened time period publish is accessible from 01/05/2024. The publish shall be based mostly in The Division of Physiology Anatomy & Genetics, Sherrington Constructing, Parks Street, Oxford, OX1 3PT
Casual enquiries could also be directed to the DPAG HR Staff – [email protected] / Professor Stephanie Cragg –[email protected]
Time limit for functions is noon on 12/04/2024.
Interviews are prone to be held on the week commencing 29/04/2024.
Purposes are significantly welcome from ladies, black and minority ethnic candidates who’re under-represented in tutorial posts in Oxford.
We, as a Division and Neighborhood, shall be thoughtful and welcoming of all individuals, no matter age, incapacity, gender reassignment, marriage and civil partnership, being pregnant and maternity, race, faith or perception, intercourse, sexual orientation, gender id, and socio-economic background. We acknowledge societal inequalities and the way these affect us, and people round us, personally and professionally. – DPAG Assertion of Inclusion
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