Postdoctoral Research Associate or Fellow

School of Well being and Life Sciences

This new full-time submit is instantly accessible till 30 June 2026 on a set time period foundation.

The submit

The School needs to recruit two Postdoctoral Researchers to review the biology of pluripotency within the group of Prof Austin Smith. These European Analysis Council funded posts are instantly accessible to 30 June 2026. Primarily based within the interdisciplinary Residing Programs Institute, the profitable candidates will be a part of a world-leading programme of investigations into the plasticity of the pluripotency community in numerous mammals. Candidates must be motivated by basic curiosity with a selected curiosity in early growth and/or cell destiny decision-making.

Publish 1: Naïve pluripotent stem cells must date been established solely from rodents and primates. Our objective is to design signalling environments for capturing naïve pluripotent stem cells from livestock and different mammals, together with marsupials. Approaches will embody pluripotency community resetting and somatic cell reprogramming, in addition to direct derivations from livestock embryos. This submit requires cell tradition aptitude, expertise with genetic manipulations, and information of developmental signalling.

Publish 2: Mouse and human naïve pluripotent stem cells have overlapping however distinct gene regulatory networks and exhibit totally different direct lineage potencies. Our objective is to uncover the core gene regulatory community shared throughout mammalian species. Approaches will embody genetic perturbations, transcriptome and chromatin analyses, and community inference. This submit requires superior abilities in molecular cell genetics, capability to make use of fundamental sequencing evaluation pipelines, and an curiosity in molecular networks.

Each posts will contain intensive stem cell tradition experimentation together with molecular reprogramming, genetic manipulation, signalling pathway manipulation, and focused chemical and genetic screens. Transcriptomic and multimodal ‘omics analyses will probably be carried out in partnership with computational/bioinformatics members of the group.

About you

PDRA: The profitable applicant will have the ability to current info on analysis progress and outcomes, talk advanced info, orally, in writing and electronically and put together proposals and functions to exterior our bodies.

Candidates will possess a related PhD (or be nearing completion) or possess an equal qualification/expertise in a associated discipline of research and have the ability to exhibit ample information within the self-discipline and of analysis strategies and strategies to work inside established analysis programmes.

PDRF: The profitable applicant will have the ability to develop analysis targets, tasks and proposals; determine sources of analysis funding and contribute to the method of securing funds and make shows at conferences and different occasions.

Candidates will possess a related PhD or equal qualification/expertise in a associated discipline of research. The profitable applicant will probably be a nationally recognised authority within the topic space and possess ample specialist information within the self-discipline to develop analysis programmes and methodologies. The profitable applicant will even have the ability to work collaboratively, supervise the work of others and act as group chief as required.

Please make sure you learn the Job Description and Particular person Specification for full particulars of this function by clicking on the attachment.

What we will give you

• Freedom (and the assist) to pursue your mental pursuits and to work creatively throughout disciplines to supply internationally thrilling analysis;
• Assist groups that perceive the College huge analysis and educating targets and companion with our lecturers accordingly
• An Innovation, Influence and Enterprise directorate that works carefully with our lecturers offering specialist assist for exterior engagement and growth
• Our Exeter Educational initiative supporting excessive performing lecturers to realize their potential and develop their profession

• A lovely campus set within the coronary heart of beautiful Devon.

The College of Exeter

We’re a member of the distinguished Russell Group of research-intensive universities and within the prime 200 universities on the planet (Occasions Greater Training World College Rankings 2024 and QS World College Rating 2024).  We mix world-class educating with world-class analysis, reaching a Gold ranking within the Educating Excellence Framework Award 2023, underpinned by Gold rankings for Pupil Expertise and Pupil Outcomes.

Our world-leading analysis affect has grown greater than some other Russell Group college in recent times, and we’re residence to among the world’s most influential researchers, in search of to reply among the most basic points dealing with humankind at the moment.  Greater than 99 p.c of our analysis is of worldwide high quality and 47 p.c is world-leading (2021 Analysis Excellence Framework).

We encourage proactive engagement with business, enterprise and group companions to reinforce the affect of analysis and training and enhance the employability of our college students. Examine our world main analysis – Inexperienced Futures and the way we’re remodeling training for a altering world. We’re positioned in a fantastic a part of the nation and Exeter (a quick rising tech hub) is certainly one of only some UK cities to have been designated as a UNESCO Artistic Metropolis

Our Equality, Variety and Inclusion Dedication

We’re dedicated to making sure affordable changes can be found for interviews and workplaces.

While all candidates will probably be judged on benefit alone, we significantly welcome functions from teams presently underrepresented inside our working group. 

With over 30,000 college students and seven,000 workers from 150 totally different nations we provide a various and fascinating surroundings the place our range is widely known and valued as a serious power. We’re dedicated to creating an inclusive tradition the place all members of our group are supported to thrive; the place numerous voices are heard by way of our engagement with evidence-based constitution frameworks for gender (Athena SWAN and Venture Juno for Physics), race equality (Race Equality Constitution Mark), LGBTQ+ inclusion (Stonewall Variety Champion) and as a Incapacity Assured employer.

Additional info

For additional info please contact Professor Austin Smith, e-mail [email protected]