NATA Chemistry Research Scientist

The Medical Analysis Council (MRC), as a part of UK Analysis and Innovation (UKRI), has invested a complete of £30m over 4 years via the Strategic Priorities Fund to ascertain a nucleic acid remedy accelerator (NATA) that can help state-of-the-art interdisciplinary analysis to resolve essential points in nucleic acid drug supply, via centered NATA analysis challenges and a NATA infrastructure hub.

The NATA will give attention to bringing collectively key stakeholders across the infrastructure hub whereas catalysing collaborative R&D exercise with centered help to deal with vital obstacles going through oligonucleotide remedy supply to key organs. This funding will help capability constructing when it comes to gear, upskilling and area experience that might be important in growing essential mass to catalyse and de-risk the event of next-generation nucleic acid therapeutics.

UK Analysis and Innovation is a brand new entity that brings collectively 9 companions to create an unbiased organisation with a robust voice for analysis and innovation, extra data could be discovered at www.ukri.org

Band
1
 
MRC – 4

Location
1
 
Harwell Campus, Oxfordshire

Wage
1
 
£39,375 – £41,843

Contract Kind
1
 
Everlasting

Job Kind
1
 
Science

Full Time / Half Time
1
 
Full Time

Job Description
1
 
The Position

That is an thrilling position in a dynamic and rising interdisciplinary group on the NATA Hub growing new therapeutic oligonucleotides for varied translational and collaborative tasks. The Analysis Scientist will play a key position in designing, synthesising, and evaluating current and new chemical modifications for nucleic acid therapeutics. As well as, the Analysis Scientist will design and implement processes and workflows for nucleic acid synthesis, purification, and scale-up.

Foremost Tasks

• Work intently with colleagues to carry out the design, synthesis, and analysis of oligonucleotides.
• Design and implement processes and workflows for the manufacturing of oligonucleotides.
• Take a proactive strategy to studying and implementing new methods and strategies associated to oligonucleotide improvement.
• Carry out HPLC purification of oligonucleotides and associated biomolecules.
• Handle devices, reagents, and chemical sources effectively.
• Troubleshoot and upkeep of procedures and instrumentation.
• Put together knowledge sheets and reviews.
• Hold glorious scientific data and implement databases.
• Keep an excellent data of the related literature.
• Recognise alternatives for the creation of mental property and cooperate in patent safety and exploitation.
• Current work internally and contribute to lab conferences.

Different Tasks

• Assist the Lab Supervisor in endeavor lab administration duties comparable to lab and gear upkeep, well being and security administration, reagent stock and related databases.
• Assist high quality management duties when essential
• Attend related conferences and conferences.
• Undertake any essential coaching that contributes to the event of the primary obligations.

Particular person Specification
1
 
Important Choice Standards

• Maintain a PhD in a biochemistry-related area or equal analysis/trade expertise.
• Expertise working with analytical methods of biomolecules, ideally nucleic acids.
• Primary data in nucleic acid bioinformatics
• Information in oligonucleotide synthesis
• Expertise in knowledge evaluation and interpretation
• Information in HPLC purification methods
• Interdisciplinary pursuits with an emphasis on in vitro and in vivo testing
• Glorious communication abilities and efficient engagement with colleagues and collaborators
• Excessive degree of motivation and drive with the power to multi-task and prioritise work successfully.
• Self-discipline and regard for knowledge integrity, confidentiality, and safety
• Willingness to study.
• Capacity to write down scientifically.
• Able to essential considering
• Working and adhering to plain working procedures and expertise in course of evaluation and refinement
• Organised, hard-working with a robust eye for element and skill to work as a part of a group.
• Versatile and adaptable, capable of handle to vary priorities.
• Pc literacy is important for the recording and communication of outcomes.
• Capacity to work to deadlines and meet milestones.
• Good time administration and punctuality

Fascinating choice standards

• Primary data in molecular biology
• Excessive degree of laptop literacy
• Expertise in GMP/GLP and high quality methods
• Expertise within the synthesis of fluorescent-labelled oligonucleotides
• Expertise in giant knowledge set evaluation and database administration

The MRC is a superb place to work and progress your profession, be it in scientific analysis or the help capabilities.The MRC is a singular working atmosphere the place our researchers are rewarded by world class innovation and collaboration alternatives that the MRC title brings. The MRC is a wonderful place to develop your self additional and a spread of coaching & improvement alternatives might be accessible to you, together with skilled registration with the Science Council.
Selecting to come back to work on the MRC (a part of UKRI) signifies that you’ll have entry to a complete host of advantages from an outlined profit pension scheme and glorious vacation entitlement to entry to worker procuring/journey reductions and wage sacrifice cycle to work scheme, in addition to the possibility to place the MRC and UKRI in your CV sooner or later.
Our success relies upon our potential to embrace variety and draw on the talents, understanding and expertise of all our folks. We welcome purposes from all sections of the neighborhood regardless of gender, race, ethnic or nationwide origin, faith or perception, sexual orientation, incapacity or age. As “Incapacity Assured” employers, we assure to interview all candidates with disabilities who meet the minimal standards for the emptiness.
UKRI helps analysis in areas that embody animal well being, agriculture and meals safety, and bioscience for well being which incorporates analysis on animals, genetic modification and stem cell analysis. While you might not have direct involvement in this kind of analysis, you need to think about whether or not this conflicts together with your private values or beliefs.
We are going to conduct a full and complete pre-employment verify as a vital a part of the recruitment course of on all people which are supplied a place with UKRI. It will embody a safety verify and an excessive organisations affiliation verify.  The position holder might be required to have the suitable degree of safety screening/vetting required for the position.  UKRI reserves the proper to run or re-run safety clearance as required in the course of the course of employment.