Senior Scientist, Human Genetics

Job title:

Senior Scientist, Human Genetics

Company

Insmed EU Careers

Job description

Company Description:Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career. Recognitions:One of the Best Places to Work in the UKAcross our global locations, we’re dedicated to making a meaningful impact on patients’ lives while building a positive and inclusive culture. In 2024, Insmed was listed as one of the Best Places to Work in the UK by The Sunday Times—a designation based on employees’ perceptions of reward and recognition, instilling pride, information sharing, empowerment, wellbeing, and job satisfaction.Named Science’s Top Employer in 2021, 2022, and 2023Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That’s why we were named the No. 1 company to work for in the biopharma industry in Science’s Top Employers Survey for two years in a row.A Certified Great Place to Work®We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.Summary: We are looking to hire a qualified individual to join our growing Human Genetics team at Insmed. As a member of our team, you will apply your expertise in statistical genetics / bioinformatics to conduct exciting research supporting our proprietary technology platform of ‘Synthetic Rescue’ and direct target discovery. You will leverage datasets consisting of hundreds of thousands of humans to identify novel therapeutic targets and collaborate with our extensive wet lab team to drive these targets to the clinic. You will be a key member of the human genetics team and contribute to building the human genetics platform at Insmed by developing our statistical genetics platform and leading cutting edge scientific research. Responsibilities:Responsibilities:

• Work with the human genetics leadership to identify potential areas of interest for future research programs

• Conduct independent research on ‘Synthetic Rescue’ at the direction of the human genetics leadership team

• Gain access to, curate multi-omics data from, and analyze diverse publicly available data from large biobank studies

• Develop human genetic analysis workflows both locally and in cloud-based environments

• Perform ad hoc analyses and function as a subject leader in support of ongoing wet lab / informatics projects

• Partner with the informatics team to ensure reproducible informatic workflows

Required Skills:

• PhD (or equivalent experience) and 3+ years of academic postdoc or industry experience in genetics, bioinformatics, medicine, biology, biostatistics, genetic epidemiology, or similar area.

• Experience using common statistical tests and methods for genetic association (e.g. GWAS, gene burden tests, regenie, BOLT-LMM)

• Experience in visualization of genetic data (e.g., Integrative Genomics Viewer)

• Experience building or implementing scalable human genetics pipelines to perform high-throughput analysis of hundreds of thousands of individuals

• Comfortable working in a Linux or Linux-like environment (e.g., bash / shell / MacOS)

• Proficiency in Python and R

• Strong data processing, quality control, and management skills

• Proven track record taking human genetics projects from concept to completion

Preferred Skills:

• Knowledge of common bioinformatics and next generation sequencing processing and analysis workflows (e.g., GATK, bwa, plink)

• Understanding of DNANexus, the UK Biobank Research Access Platform (RAP), or remote / cloud environments (e.g., AWS / gcloud / Microsoft Azure)

• Knowledge of generalized linear modeling, simulation of data, and design of ad hoc statistical tests

• Familiarity with wet-lab approaches for validation of human genetics targets

• Knowledge of Proteomics methods and workflows (e.g., SOMALogic / O-Link)

• Strong presentation, visualization, and communication skills

Travel Requirements:N/A Compensation & Benefits:We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world. Additional Information:Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.Applications are accepted until the position is filled.

Expected salary

Location

Cambridgeshire

Job date

Sat, 31 Aug 2024 01:43:05 GMT

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