Cryo Electron Microscopy Facility Manager

Job title:

Cryo Electron Microscopy Facility Manager

Company

King’s College London

Job description

King’s College London (KCL) is seeking a highly motivated cryo-electron microscopy (cryo-EM) expert to manage its newly established Cryo-EM Structural Discovery Facility.The new high-resolution cryo-EM facility was established following KCL’s acquisition of a 200 keV JEOL cryoARM200 cold-FEG autoloading electron microscope with an energy filter and the latest-generation Gatan K3 camera. The facility sits within the Research Platforms team, part of the Research Management and Innovation Directorate (RMID) and operates in close collaboration with the Centre for Ultrastructural Imaging (CUI), which provides additional cryo-EM sample preparation/vitrification, storage equipment and side-entry holder electron microscopes for sample screening. Whilst suitable of collecting data capable of producing
3 Å resolution reconstructions of typical macromolecular samples itself, the cryoARM also serves as a “feeder” instrument for data collection at 300 keV on the LonCEM Titan Krios microscope (of which KCL has a share).About the roleThis is an exciting opportunity to contribute to cutting-edge structural biology research through single-particle cryo-electron microscopy and cryo-electron tomography, while playing a pivotal role in the operation and development of the facility.The Facility Manager will be responsible for electron microscope operation and the management, support and future development of the facility, in a financially sustainable manner. The post holder will support multiple projects simultaneously and deliver high-quality training and technical assistance to a range of internal and external academic and industrial researchers, offering expert advice to meet their research objectives while optimising the facility’s utilisation.This is a senior role in cryo-EM, requiring a high level of technical expertise and strategic leadership within the field. The successful candidate will have in-depth knowledge and hands-on experience in single-particle cryo-EM, including sample preparation, instrument operation for sample screening and automate data acquisition, and image processing. In addition to their technical expertise, they will play a key role in driving the strategic development of the facility, optimising workflows, and implementing best practices to enhance efficiency and research output. Strong organisational and leadership skills are essential to ensure the facility operates effectively and continues to evolve in line with advancements in cryo-EM technology and align with the strategic goals of Research Platforms, RMID and King’s.This is a full-time post (35 Hours per week), and you will be offered an indefinite contract.About youTo be successful in this role, we are looking for candidates to have the following skills and experience:Essential criteria * PhD qualified in relevant subject area, or equivalent

• Expertise in cryo- TEM operation, including screening and high-resolution data collection
• An in-depth working knowledge of current methods and procedures for cryo-EM specimen preparation and imaging technology.
• Experience in training new users and facilitating access to high-end instrumentation.
• Experience with cryo-EM data collection software (most desirably SerialEM and/or Gatan Latitude).
• Knowledge of some elements of facility management, for example – dealing with day-to-day operations in a similar facility, staff supervision, procurement or financial processes.
• A good understanding of health and safety procedures and its implementation in the workplace.
• Excellent communication skills, along with strong interpersonal skills, including ability to engage senior management and communicate with staff at all levels.

Desirable criteria * Experience with the maintenance and basic troubleshooting of Cryo- TEMs

• A good understanding of cryo-EM data management, such as data transfer and storage, and network clustering.
• Experience in and/or an understanding of FIB-milling and/or cryo-CLEM methodologies
• Experience in facility pricing, budget management and reporting.
• Proficiency using data processing software packages (CCPEM, CryoSPARC, Relion, IMOD, etc.)

Downloading a copy of our Job DescriptionFull details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.Further InformationWe pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King’s.We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.To find out how our managers will review your application, please take a look at our ‘ ‘ pages.Interviews are due to be held on 19th and 20th MarchWe are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.Grade and Salary: £52,874 – £61,921 per annum, including London Weighting Allowance
Job ID: 107305
Close Date: 04-Mar-2025
Contact Person: Charles Curtis
Contact Details:CompanyKing’s College London is one of the top 20 universities in the world and among the oldest in England. King’s has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.King’s has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.King’s has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.King’s College London and Guy’s and St Thomas’, King’s College Hospital and South London and Maudsley NHS Foundation Trusts are part of King’s Health Partners. King’s Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world’s leading research-led universities and three of London’s most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: .King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at .Company info Mini-site Telephone +(44)02078365454 Location STRAND
LONDON
WC2R 2LS
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Expected salary

£52874 – 61921 per year

Location

London

Job date

Sun, 16 Feb 2025 08:22:43 GMT

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