University of Sheffield
About the Project
Project description:
Antimicrobial resistance (AMR) is one of the biggest global challenges to human health in the 21st century, with the worst-case scenario development of a raft of incurable infections, especially Hospital Gram negative pathogens. Hence development of novel, cheap antimicrobials is essential if we are to combat this problem.
One such target is transporters that exist in most Gram negative bacteria and pathogens that transport essential nutrients into the cells. Their inhibition using novel synthetic peptides is one of these options.
In this project you will develop and test a range of these inhibitory peptides, based on prototypes already developed in the lab. In parallel you will develop a recombinant method of peptide production that will enable cheap manufacturing of peptide cocktails to inhibit growth of a range of AMR pathogens via inhibition of the TonB transport system of these bacteria.
You will receive a broad training in microbiology, bioinformatics, recombinant technology, protein purification, microscopy and other molecular techniques. You will join a vibrant lab with an excellent track record of supervision and PhD student publications.
For more information contact Professor Graham Stafford ([email protected]) or visit our website (https://stafford.sites.sheffield.ac.uk/). We welcome applications from enthusiastic, committed and innovative candidates.
The Faculty of Health is offering a number of scholarships for the academic year 2024/5 for eligible students. This project is being considered for the Faculty, PGT>PGR and Underrepresented Student scholarship schemes. You do not need to apply more than once as your application will automatically be considered for all scholarships based on your eligibility criteria.
Students worldwide are welcome to apply but will need to fund the overseas fee difference of around £24,000 per year but will not be eligible for the Underrepresented Student scheme.
PGT>PGR
We are accepting applications from current and past (who have graduated in 2022 & 2023) PGT students from the Faculty of Health.
Underrepresented Student
We are accepting applications for the University of Sheffield Research Scholarships for Black or Black British (of African or Caribbean heritage), Asian or Asian British (of Bangladeshi, Pakistani and Indian heritage) or multiple ethnic background including one of the ethnicity groups listed above.
The University of Sheffield is committed to increasing opportunities in doctoral research for particular minoritised students who are currently under-represented in our postgraduate research student population.
Candidates will be required to complete a declaration form and upload it to their application. Applicants with overseas fee status are NOT eligible for these awards.
How to apply:
Please complete a University Postgraduate Research Application form available here: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying. Candidates applying for the BAME scheme will be required to complete a declaration form and upload it to their application.
Please clearly state the prospective main supervisor in the respective box and select ‘School of Clinical Dentistry’ as the department.
Proposed start date:
October 2024
Entry Requirements:
Candidates must have a first or upper second class honours degree or significant research experience.
To help us track our recruitment effort, please indicate in your email – cover/motivation letter where (globalvacancies.org) you saw this job posting.