MALDI
mass spectrometry has been a cornerstone of modern biological mass
spectrometry, enabling the soft ionization, analysis and characterisation of
large biomolecules such as proteins. It has been a game changer in areas such
as clinical microbiology and imaging as well as in the analysis of synthetic
polymers and other macromolecules. This project will take the conventional
solid (crystalline) MALDI methodology to the next level by further developing
and advancing its liquid counterpart. As shown in our previous work, liquid
MALDI as applied to modern atmospheric pressure mass spectrometers can
advance MALDI analysis by adding greater ion signal stability, faster
sample-to-sample analysis times and ESI-like ion formation, leading to
mutliply charged analyte ions. These advantages will be further investigated
and applied to a range of applications and analyte molecules. Possible
application areas are clinical and veterinary diagnostics, environmental
analysis, forensics, pharmaceutical analysis, and industrial polymer
analysis. Applicants can express interest by providing a CV or they can
submit a formal application through the university systems using the
following link: http://www.reading.ac.uk/pgapply – any questions on the
application process should be directed to chem-pgadmin@reading.ac.uk.
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