Analytical Development Scientist

Job title:

Analytical Development Scientist

Company

Cranleigh Recruitment

Job description

An exciting opportunity is available for an Analytical Development Scientist to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities:The purpose of this role is to develop analytical methodologies part of an innovative multidisciplinary team that will develop the next generation of mammalian expression systems & cells lines to enable highly productive pharmaceutical bioprocesses and, ultimately, more cost effective Immunotherapeutics.

• Design, plan, and develop analytical assays utilising a variety of different techniques and throughputs ensuring that deliverables are successfully met within timelines
• Execute analytical assays with a high level of skill and in a reliable and reproducible way
• Author SOPs, training documents & COSHH forms as key deliverables
• Train team members to a high degree of competence to ensure data integrity
• Document research findings clearly in a lab book
• Communicate regularly in group meetings and prepare and deliver presentations to project team and internal stakeholders
• Along with team members, provide routine laboratory maintenance, including participating in equipment upkeep, cleaning rotas and laboratory consumables stock management
• Shared responsibility for out-of-hours cell culture maintenance.
• Ensure that laboratory health, safety and quality procedures are followed
• Support the preparation of laboratory risk assessments and maintenance of health and safety protocols
• Maintain the confidentiality of the project and protocols
• Keep abreast of current technologies and relevant scientific literature to help identify opportunity for improvements and reduction of costs

Minimum Required Qualifications

• MSc/PhD in Biochemistry, Molecular Biology or related field
• MSc with 5+ years of industry experience or PhD with 2 years industry experience

Essential Experience:

• Extensive experience of developing and executing a range of analytical methodologies including HPLC/UPLC & LC-MS to characterise antibody titre and CQAs
• Experience of developing high-throughput analyses within automated target discovery pipelines
• Evidence of executing a range of molecular and cell biology assays to a high standard including FACS, qRT-PCR, Western Blotting & ELISA
• Skilled in experimental design and troubleshooting
• Application of Design of Experiments (DOE) to rationalise experiment design
• Experience of writing SOPs, training documents and risk assessment
• Experience of training other team members to a high level of competency
• Experience of working with bioprocess relevant cell lines eg. CHO or HEK293
• Familiarity of mammalian cell line development including generation of GM/GE cell lines, single cell cloning and CRISPR / ORF library screens
• Skilled in molecular biology techniques including PCR, qRT-PCR, Western Blot, ELISA, plasmid preparation, plasmid cloning, site directed mutagenesis & FACS
• Ability to work independently and as part of team
• Experience of planning experiments with a given timeframe
• Good numeracy, computer and communication skills

Desirable Experience:

• Experience with automation and high-throughput technologies applied to mammalian cell line generation eg. Beacon, 96 deep well plate model systems & Ambr15
• Familiarity of working with large datasets including transcriptomic / proteomic datasets
• Experience of mammalian cell culture and related techniques including passaging, banking, transfection, nucleofection & genotyping
• Experience of working safely with 3rd generation lentiviral plasmid systems within a CAT2.0 environment

Skills and personality:

• Innovative mindset
• Advanced problem-solving skill
• Enthusiasm and initiative
• Driven to deliver
• Reliable and responsible
• Able to multitask
• Good time management and organisation skills
• Excellent communication skills both written and spoken
• Happy in a growing and multi-disciplinary team

Expected salary

Location

Oxfordshire

Job date

Sat, 21 Dec 2024 07:34:21 GMT

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