Job title:
Analytical Development Scientist
Company
Cranleigh Recruitment
Job description
An exciting opportunity is available for an Analytical Development Scientist to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities:The purpose of this role is to develop analytical methodologies part of an innovative multidisciplinary team that will develop the next generation of mammalian expression systems & cells lines to enable highly productive pharmaceutical bioprocesses and, ultimately, more cost effective Immunotherapeutics.
- Design, plan, and develop analytical assays utilising a variety of different techniques and throughputs ensuring that deliverables are successfully met within timelines
- Execute analytical assays with a high level of skill and in a reliable and reproducible way
- Author SOPs, training documents & COSHH forms as key deliverables
- Train team members to a high degree of competence to ensure data integrity
- Document research findings clearly in a lab book
- Communicate regularly in group meetings and prepare and deliver presentations to project team and internal stakeholders
- Along with team members, provide routine laboratory maintenance, including participating in equipment upkeep, cleaning rotas and laboratory consumables stock management
- Shared responsibility for out-of-hours cell culture maintenance.
- Ensure that laboratory health, safety and quality procedures are followed
- Support the preparation of laboratory risk assessments and maintenance of health and safety protocols
- Maintain the confidentiality of the project and protocols
- Keep abreast of current technologies and relevant scientific literature to help identify opportunity for improvements and reduction of costs
Minimum Required Qualifications
- MSc/PhD in Biochemistry, Molecular Biology or related field
- MSc with 5+ years of industry experience or PhD with 2 years industry experience
Essential Experience:
- Extensive experience of developing and executing a range of analytical methodologies including HPLC/UPLC & LC-MS to characterise antibody titre and CQAs
- Experience of developing high-throughput analyses within automated target discovery pipelines
- Evidence of executing a range of molecular and cell biology assays to a high standard including FACS, qRT-PCR, Western Blotting & ELISA
- Skilled in experimental design and troubleshooting
- Application of Design of Experiments (DOE) to rationalise experiment design
- Experience of writing SOPs, training documents and risk assessment
- Experience of training other team members to a high level of competency
- Experience of working with bioprocess relevant cell lines eg. CHO or HEK293
- Familiarity of mammalian cell line development including generation of GM/GE cell lines, single cell cloning and CRISPR / ORF library screens
- Skilled in molecular biology techniques including PCR, qRT-PCR, Western Blot, ELISA, plasmid preparation, plasmid cloning, site directed mutagenesis & FACS
- Ability to work independently and as part of team
- Experience of planning experiments with a given timeframe
- Good numeracy, computer and communication skills
Desirable Experience:
- Experience with automation and high-throughput technologies applied to mammalian cell line generation eg. Beacon, 96 deep well plate model systems & Ambr15
- Familiarity of working with large datasets including transcriptomic / proteomic datasets
- Experience of mammalian cell culture and related techniques including passaging, banking, transfection, nucleofection & genotyping
- Experience of working safely with 3rd generation lentiviral plasmid systems within a CAT2.0 environment
Skills and personality:
- Innovative mindset
- Advanced problem-solving skill
- Enthusiasm and initiative
- Driven to deliver
- Reliable and responsible
- Able to multitask
- Good time management and organisation skills
- Excellent communication skills both written and spoken
- Happy in a growing and multi-disciplinary team
Expected salary
Location
Oxfordshire
Job date
Sat, 21 Dec 2024 07:34:21 GMT
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