Bioinformatician

Job title:

Bioinformatician

Firm

Newcastle College

Job description

Wage: £33,966 to £44,263 each year

Newcastle College is a superb place to work, with glorious . Now we have a beneficiant vacation bundle; plus the chance to purchase extra, nice pension schemes and various well being and wellbeing initiatives to assist you.

Closing Date: 26 March 2024

The Position

The principal function of this position is to offer bioinformatics management and assist to the Newcastle NHS Extremely Specialised Mitochondrial Diagnostic Laboratory, based mostly throughout the Wellcome Centre for Mitochondrial Analysis (WCMR) within the School of Medical Sciences, Newcastle College.

You’ll drive, coordinate and assist informatics evaluation throughout a broad portfolio of tasks within the laboratory which is built-in into NHS Genomic Service supply as part of the North East and Yorkshire Genomic Laboratory Hub. Professor Rob Taylor (Head of Laboratory) and Dr Emma Watson (Deputy Head of Laboratory) are leads of a Work bundle throughout the NHS Genomic Community of Excellence for Uncommon and Inherited Illness, which is funded for 2 years to drive analysis exercise into new and improved diagnostic checks throughout the nationwide Genomic Medication Service and speed up entry the genomic medication within the NHS ( ).

Partnering with tutorial colleagues within the UK, the Mitochondrial Extremely Specialised Service groups in Oxford and London and Genomics England you’ll develop, check and preserve novel analytical pipelines for diagnosing mitochondrial illness from short-read and long-read complete genome sequencing information, to ship a nationwide technique for precisely name and reporting clinically actionable mitochondrial DNA sequence variants.

Alongside this, and within the context of exercise throughout the Educational Centre, additionally, you will assist researchers utilizing multidimensional datasets, together with complete exome and genome sequencing, RNA sequencing, proteomic and metabolomic information from patient-derived pathological samples and experimental fashions, with the purpose of bettering our understanding of mitochondrial biology and illness mechanisms and contributing to work aimed toward growing novel therapies.

We’re searching for a dynamic particular person with a robust background in bioinformatics to hitch our 20-strong NHS Extremely Specialised Diagnostic Laboratory group ( ), working with colleagues throughout the Centre who’ve a world repute for his or her experience in understanding the health-related outcomes of mitochondrial illness, related illness mechanisms and improvement of novel therapies.

It is best to have a confirmed monitor file (evidenced by publications and/or expertise in a earlier position) and present an enthusiasm and mental curiosity to use a broad vary bioinformatics instruments and pipelines to understanding mitochondrial illness development and complexity.

This put up supplies an thrilling alternative for a person with bioinformatics experience.

Candidates ought to connect an announcement to their utility that describes their analysis pursuits and, particularly, highlights their related expertise.

This full time put up is obtainable on a set time period foundation till 31 March 2026.

You’ll work carefully with ( ) and , to whom casual enquiries may be made.

Discover out extra in regards to the School of Medical Sciences right here:

Discover out extra about our Analysis Institutes right here:

As a part of our dedication to profession improvement for analysis colleagues, the College has developed 3 ranges of . These profiles set out firstly the generic competences and obligations anticipated of position holders at every degree and secondly the overall {qualifications} and experiences wanted for entry at a selected degree.

Key Accountabilities

• To develop, improve and take part within the supply of genomic testing throughout the laboratory, particularly the design of protocols, subsequent evaluation and the interpretation of informatic outputs referring to mitochondrial DNA sequence variation from Entire Genome Sequencing datasets. This can even contain collaboration with researchers throughout the Wellcome Centre group, different tutorial mitochondrial researchers and their groups, Genomics England and the broader Extremely Specialised Mitochondrial Laboratory community
• To develop and preserve novel computational pipelines for the evaluation of next-generation sequencing information (genomic, transcriptomic and epigenetic) and high-dimensional proteomic information (deep phenotyping) derived from cutting-edge WCMR tasks
• To supply assist and informatic steerage for the bioinformatic evaluation of publicly accessible ‘omics’ datasets (i.e. Genomics England and UKBiobank) and to help within the improvement of analysis tasks utilizing this information
• The post-holder will probably be inspired and mentored to develop their very own, impartial analysis areas which align with the Centre methods, imaginative and prescient and group working
• Recurrently appraise and check new software program and instruments to make sure that the sequencing and proteomic information evaluation, annotation and interpretation pipelines are up-dated successfully
• Preserve a excessive degree of up-to-date specialist information of bioinformatics, by studying related journals and collaborating in related conferences, in order to assist WCMR in making strategic selections on computational infrastructure purchases and upgrades
• Liaise with native IT departments (NHS and College) to successfully adapt {hardware} to fulfill person calls for – processing energy and information storage and so on. and safeguard the reliability and validity of information in any respect phases of study utilizing acceptable high quality management and model management procedures and the follow of reproducible analysis
• Another duties throughout the remit of the grade as required by the Head of Educational Unit

The Particular person

Information, Expertise and Expertise

• Expertise working with a Unix/Linux HPC computing surroundings, with expertise in related/present programming languages (i.e. Python and so on)
• Expertise accessing and using exterior, publicly accessible datasets (i.e. Genomics England 100k information, UKBioBank and EBI)
• Expertise analysing, visualizing and annotating excessive throughput sequencing or proteomics information units and disseminating this information to non-informatic researchers
• An in-depth specialist understanding and curiosity in analysis and doable acquisition of the newest breakthrough applied sciences in bioinformatics and computational biology, alongside a grounded, theoretical, information of genetic, cell and molecular biology
• Expertise of labor as a bioinformatician in a analysis setting
• Related IT expertise

Fascinating

• Expertise with a programming language for utility improvement
• Proficiency utilizing statistical packages (i.e., R)
• Expertise of working with mitochondrial DNA sequences, and information of mitochondrial genetics
• Expertise working with massive quantity information units (e.g., differential gene expression, exome or genome sequencing).
• Direct expertise of single cell transcriptomic, epigenetic, proteomic and genomic datasets.
• Information of SQL databases, net improvement.
• Information of LIMS design and implementation.
• Proof of contributing to profitable purposes for nationwide/worldwide peer reviewed analysis funding
• Proof of accomplished analysis and publications in peer reviewed journals
• Expertise within the design and evaluation and supply of analysis tasks

Attributes and Behaviour

• Glorious interpersonal and communication abilities (each written and oral) to have the ability to work alongside people with totally different ranges of technical information
• Hold updated with new / improved bioinformatics information, abilities, methods and analysis
• Excessive degree of motivation and initiative
• Glorious organisational abilities
• Robust group participant
• Inventive downside fixing
• Robust consideration to element
• Capability to work flexibly
• Capability and willingness to journey regionally and throughout the UK for conferences and conferences

Fascinating

• Information and understanding of the regulatory framework and good analysis follow underpinning analysis
• Understanding of well being and security rules and procedures inside the next training surroundings
• Define understanding of UK analysis funding procedures

{Qualifications}

• Related Bioinformatics expertise in a scientific and/or technical position, ideally with postgraduate diploma degree (e.g., MSc.) coaching in bioinformatics or equal {qualifications}
• A PhD as a result of alternative to interact with and develop tutorial endeavour by this put up

Newcastle College is a world College the place everyone seems to be handled with dignity and respect. As a College of Sanctuary, we goal to offer a welcoming place of security for all, providing alternatives to individuals fleeing violence and persecution.

We’re dedicated to being a completely inclusive college which actively recruits, helps and retains colleagues from all sectors of society. We worth range in addition to have a good time, assist and thrive on the contributions of all of our staff and the communities they symbolize. We’re proud to be an equal alternatives employer and encourage purposes from people who can complement our current groups, we consider that success is constructed on having groups whose backgrounds and experiences mirror the variety of our college and scholar inhabitants.

At Newcastle College we maintain a silver award in recognition of our good employment practices for the development of gender equality. We additionally maintain a Bronze award in recognition of our work in direction of tackling race inequality in larger training REC. We’re a employer and can supply an interview to disabled candidates who meet the important standards for the position as a part of the supply and interview scheme.

As well as, we’re a member of the Euraxess initiative supporting researchers in Europe.

Requisition ID: 26734

Anticipated wage

£33966 – 44263 per yr

Location

Newcastle

Job date

Wed, 06 Mar 2024 23:15:34 GMT

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