Clinical Research Fellow

Job title:

Scientific Analysis Fellow

Firm

British Medical Journal

Job description

The UCL Huntington’s Illness Centre is uniquely positioned world-wide to translate mechanistic insights to ‘first in human’ research. It combines refined cell-based methods with rigorously standardised preclinical goal validation to prime mechanistically-driven drug improvement initiatives. The Centre integrates scientific and laboratory work with small proof-of-concept first in human research in sufferers within the Leonard Wolfson Experimental Neurology Centre (LWENC) previous to initiating bigger section 2 and three scientific trials together with novel huntingtin-lowering trials.We’re recruiting a Scientific Analysis Fellow to affix the Centre to work on the Deal with-HD mission, an progressive research funded by Wellcome and led by Professor Sarah J Tabrizi, that seeks to additional perceive neurodegeneration utilizing HD as a mannequin dysfunction. That is an thrilling alternative to affix a world main analysis group who’re main the best way in creating and testing novel therapies for HD sufferers. We now have robust partnerships with biotech and pharmaceutical corporations in addition to collaborations with quite a few worldwide educational analysis teams.You’ll primarily drive the scientific goals of our HD Younger Grownup Examine (HD-YAS): to find out early systems-level pathology and affect on symptomatology in younger grownup HD gene carriers and to determine goal engagement and efficacy markers for future therapeutic trials.This key put up inside Professor Tabrizi’s workforce will present distinctive analysis and scientific expertise in neurogenetics, neurodegenerative illnesses, Huntington’s illness, motion issues, 3T and 7T neuroimaging, CSF biology and biomarkers and cognitive neuroscience.Additionally, you will have the chance to develop into concerned within the early section gene remedy and antisense oligonucleotide therapy trials ongoing in HD. You’ll be an integral a part of the HD Analysis Centre, taking part within the multidisciplinary HD and neurogenetics clinics on the NHNN, beneath the scientific supervision of Professors Sarah Tabrizi and Edward Wild. You’ll have the prospect to review for the next diploma, benefitting from educational help from world leaders within the subject and entry to our distinctive cohort with deep phenotyping throughout a number of domains together with biofluids, excessive subject neuroimaging and behavioural information.The put up is obtainable from 01 August 2024, funded by a mixture of philanthropic and analysis grant funding for 3 years within the first occasion.In the event you want affordable changes or a extra accessible format to use for this job on-line, or have any queries concerning the appliance course of, please contact the Institute HR Staff (ion.hradmin at ucl.ac.uk).For a full job description and to use for this position please go to UCL’s on-line recruitment portal (https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs) and search utilizing emptiness reference B02-06685.You may be a registered medical practitioner, permitted to practise within the UK on the graduation of put up, have accomplished common medical coaching to ST2 or equal degree, and possess a really excessive degree of consideration and take care of sufferers and analysis topics. Expertise of working in neurology and an curiosity in neurodegenerative illnesses is important, as is demonstrable proficiency in lumbar puncture and the power to work co-operatively in a multidisciplinary setting. Expertise of scientific/translational analysis and of working in Huntington’s illness is fascinating.The position is obtainable within the vary of £43,619 – £67,652 every year together with London Allowance, on the CL, JDPS, or StR scale, depending on NHS contract and/or stage of scientific coaching.In addition to the thrilling alternatives this position presents, we additionally supply some nice advantages; go to https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to seek out out extra.

Anticipated wage

£43619 – 67652 per yr

Location

London

Job date

Fri, 22 Mar 2024 01:32:49 GMT

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