Clinical Research Training Fellow

University of Oxford

About the role

We have an exciting opportunity to join Department as a Clinical Research Training Fellow.

This three-year Fellowship is aimed at clinical trainees, providing them with an opportunity to study in a high calibre research environment, working towards a DPhil.

The Fellowship is structured around an existing project designed by Professor Eric O’Neill, which will provide a first-class research environment for a clinician scientist and will have a framework for research and training in the combined fields of basic science and clinical medicine.  This training Fellowship will be tailored to form a partnership between basic scientists and clinician-scientists, with the aim to bridge the gap between basic and applied research.

This project will characterise the establishing tumour immune-microenvironment (TIME) in pre-neoplastic tissue to identify key events that result in tumour initiation, but also highlight how evasion mechanisms get embedded and therefore potential intervention strategies for PDAC.

The KPC model (LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre) is a well-defined mouse model of human pancreatic cancer and this rapidly develops spontaneous tumours. The KC model (KrasG12D/+;Pdx-1-Cre) allow identification of early PanIN lesions, with a subset going onto form PDAC with a long latency that more closely mirrors the human condition. We aim to utilise syngeneic orthotopic injection of KPC tumour cells or KC pancreatic ductal organoids together and KC mice to interrogate the immune landscape of benign vs pre-cancerous lesions. We also aim to validate findings in ex-vivo tissue slices of resected PDAC vs comparative healthy tissue, where live tissue responses to interventions can be monitored in real-time.

About you

You will have a strong academic track record, e.g. a BSc (or equivalent) with a 1st or 2:1; honours or distinction in the MB finals, with an interest in oncology.

You must be a GMC registered Medical Practitioner with full-time hospital service in the SHO or higher grade (or have the ability to successfully obtain GMC registration) and practice in the UK. Successful applicants will be required to hold an honorary clinical contract and therefore must ensure that they have fulfilled all the criteria required of the General Medical Council and National Health Trust.

You will possess adequate clinical experience and MRCP or appropriate post-graduate qualifications and have the motivation to pursue a career in academic medicine and demonstrable commitment to cancer research.

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.

Only applications received before noon on 23rd June 2023 can be considered.

Committed to equality and valuing diversity

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