Computational Structural Biologist

Job title:

Computational Structural Biologist

Firm

PROTEINQURE INC.

Job description

At ProteinQure, we’re constructing a computational platform for design of protein therapeutics. Our mission is to assist to create a world the place medication are engineered, not found. We work on remedies for most cancers, diabetes, bronchial asthma, and cardiovascular illnesses, amongst others, and companion with business leaders in drug discovery to generate novel therapeutics exterior of the traditional chemical house.

Our expertise combines computational biophysical fashions with statistical and machine studying approaches to allow us to go looking throughout huge areas of protein therapeutics. We construct and deploy these computational modules utilizing a scalable cloud computing infrastructure and complement their predictions with outcomes from moist lab experiments.

Tasks:

• Develop novel drug candidates utilizing our computational protein design platform with educational and business companions
• Execution of protein design workflows (construction and property prediction)
• Knowledge evaluation and visualization for studies/shows, supply to companions
• Orchestrate platform validation for retrospective and potential functions (could contain shut interplay with experimental biologists at ProteinQure/CRO)
• Summarize and disseminate analysis on drug discovery targets, therapeutic modalities, and computational methodologies, to information inner drug discovery and software program growth.
• Work side-by-side with chemists, biologists, pc scientists, and software program builders to develop new strategies for protein design
• Help within the assortment/curation of organic datasets (sequence, construction, operate knowledge) for machine studying initiatives
• Identification of platform limitations and growth of analysis methods to resolve these points.

Necessities:

• PhD (or 2+ years expertise) in Biochemistry, Bioinformatics, Biophysics or comparable subject
• Consolation explaining technical ideas to a various viewers
• Peer-reviewed publications on protein engineering, design, construction and performance OR Case research from time in business

Good to haves:

• Expertise with molecular modelling software program (Rosetta, BioLuminate, MOE)
• Confidence with molecular visualization software program (PyMol, Chimera, VMD)
• Scripting expertise (Python) and data of biology knowledge codecs (PDB)
• Expertise with biophysical experiments (NMR, EPR, FRET, X-ray crystallography, and many others.) or measuring protein-protein interactions (SPR, ITC, phage show)

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Anticipated wage

Location

Toronto, ON

Job date

Thu, 04 Jan 2024 06:43:43 GMT

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