Cryo-EM Facilities Manager

Job title:

Cryo-EM Facilities Manager

Company

GlaxoSmithKline

Job description

Cryo-EM Facilities ManagerThe UK Structural & Biophysical Sciences group is a global multi-disciplinary department within GSK R&D that provides molecular insights into drug discovery for small molecule, oligonucleotide, biopharmaceutical and vaccine programs.This role is an excellent opportunity for a team-oriented individual who is keen to apply their skills in managing a highly productive cryo-EM facility. As a key member of a team of over a dozen accomplished structural biologists, you will hold the crucial responsibility of operating and maintaining three state-of-the-art cryo-EM microscopes. Your role will encompass troubleshooting, calibration, and regular upkeep to ensure optimal performance.In this pivotal role in drug discovery, you will collaborate with researchers both within and outside the department, leveraging cryo-EM to directly impact the advancement of medicines. You will also have the unique opportunity to share your expertise, guiding and nurturing a team of passionate individuals in the use of cryo-EM technology.Staying abreast of the latest developments in cryo-EM technology is vital, ensuring that our team and facility remain at the forefront of the field. If you have an aptitude and knowledge of related topics of data processing, computational infrastructure, sample preparation, cryo-ET, or knowledge of other structural methods, we would be eager to leverage and maximise your potential within the department.In this role you will:

• Oversee and operate three state-of-the-art cryo-EM microscopes, ensuring their optimal performance. This includes troubleshooting, calibration, regular upkeep, and knowledge of relevant site facilities.
• Foster collaborative environment that encourages innovation and high productivity in application of cryo-EM in drug discovery.
• Help design future cryo-EM infrastructure strategy and evolve efficient ways of working.
• Establish strong and productive relationships with manufacturers to ensure the best support and updates for the equipment.
• Ensure awareness of developments in cryo-EM to maintaining the department at the forefront of field.
• Adherence to the highest standards of quality and safety.

Why you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:

• A background in a biological, biochemical or physical sciences discipline, with at least PhD level or equivalent experience.
• Extensive experience with operation of screening and high-resolution data-collection microscopes.
• Knowledge of all stages of single particle cryo-EM process from protein purification to grid optimisation, data-processing, 3-D reconstruction and structure interpretation.
• Exceptional interpersonal, communication and team working skills.
• Excellent organisational skills.

Preferred Qualifications & Skills:Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Postdoctoral/industrial experience in structural biology.
• Examples of training scientists in one or more areas of the cryo-EM process.
• Experience of integration of microscope data into HPC ecosystems.
• Experience with imaging broad range of samples e.g. soluble and membrane proteins, small proteins

100kDa, LNP, etc. * Experience with cryo-ET.

• Experience of maintaining microscopes and interacting with external support/ engineers.

Closing Date for Applications: 14th October 2024Please take a copy of the Job Description, as this will not be available post closure of the advert.When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Wed, 25 Sep 2024 06:19:46 GMT

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