Design of metamorphic proteins for stimuli-responsive nanomaterials

Project Description

The classic structure-function paradigm of proteins contends that a protein exhibits a single well-defined folded structure that gives rise to its biological function. Nonetheless, a growing number of “metamorphic” proteins have been discovered that interconvert between different folded conformations in response to environmental stimuli. Harnessing the ability of metamorphic proteins to change shape should enable the creation of reconfigurable nanomaterials for material applications. In this project, you will apply protein engineering methodologies to create protein biomaterials that change structure in response to environmental stimuli. Specifically, you will learn a variety of protein engineering and structural biology techniques to build proteins and apply these proteins that have never existed before to control nanomaterials. You will join a highly interdisciplinary team of researchers within the School of Biotechnology and Biomolecular Sciences at UNSW, and be part of a collaborative team environment. Furthermore, you will also engage regularly with external research collaborators, which may provide opportunities to conduct research at interstate and international universities.

Funding

The project is supported by a fully-funded PhD scholarship at the University of New South Wales. The scholarship will be funded from a recently commenced, externally-funded research projects. For successful applicants, the scholarship fully covers the university fees and research expenses and provides stipend to cover living costs for 3.5 years. You will also be supported with a conference travel allowance during the candidature.

Applying

Prospective PhD students who have graduated or expecting to graduate with a degree in Molecular Biology, Biochemistry, Biotechnology, or related disciplines, with at least a GPA of 8 out of 10, 3.5 out of 4.0, or distinction, or equivalent are invited to apply.

If you meet the HDR admission requirements, please send an email directly to Dr Dominic Glover (d.glover@unsw.edu.au) with the following information:

Email subject: Prospective PhD for protein engineering

Email body (please provide):

– Your background, experience, and research interests.

– GPA / result of each degree.

– Transcripts

– Details of any publications, along with DOI links.

– List of any other relevant research achievements.

– When you expect to be able to start your PhD if successful.

 Attachments: CV, academic transcripts, and an additional PDF file which includes certificates of prizes, awards, recognitions or any other supporting evidence.

We apologise that due to the large number of applications typically received, it is not possible to respond to all applicants.