Doctoral Candidate

Job title:

Doctoral Candidate

Company

University College London

Job description

About us The Chemistry Department at University College London is the oldest in England, with 100% of its outputs ranked as being world-leading (4*) or internationally excellent (3*) in the recent REF2021. We are located in Bloomsbury, at the heart of London, and offer an exciting and vibrant environment in which to study in one of the UK’s top universities. The Department of Chemistry at UCL is committed to supporting excellence in both research and teaching. The department offers undergraduate BSc and MSci programmes in Chemistry and currently teaches ~650 undergraduates registered in Chemistry as well as students who select Chemistry on the Natural Sciences programme and first year Chemistry for life scientists. The Chemistry Department has over 60 members of academic staff carrying out world-leading research. We specialise in the areas of organic synthesis, chemical biology, computational chemistry, nanotechnology, inorganic and materials chemistry, physical chemistry and chemical physics. The department has an annual research income of around £15 million, derived from many sources including the Research Councils (EPSRC, BBSRC, MRC, and NERC), European Commission and a wide range of charities and industrial partners in the UK, Europe and the USA. Details about our research can be found on the departmental website http://www.ucl.ac.uk/chemistry.About the role Applications are invited for a Doctoral Candidate to work in the group of Professor Alethea Tabor in the Department of Chemistry at University College London. This position is part of a HORIZON-MSCA “Macrocycles for Drug Design” (MC4DD) Doctoral Training Network, which aims to train the next generation of European medicinal chemists in a multidisciplinary environment to investigate macrocycles as new drug modalities. This position will use synthetic organic chemistry and solid-phase peptide synthesis techniques to develop methodology for the generation, screening and analysis of low-peptide macrocycles targeted to cyclophilin. This will involve the synthesis of orthogonally protected building blocks and the development of new solid-phase methodology for incorporating these into libraries of macrocycles. The project will also involve structural analysis by NMR, molecular modelling and the development of library screening techniques. The position is funded for 36 months and the work is expected to lead to the award of a PhD. The position will start between 1/11/2024 and 31/5/2025.A full job description and Person Specification can be accessed at the bottom of this page. Please write your application in English and upload the following with your application:

• A cover letter explaining your motivation for applying for the post, understanding of the research project, and previous research experience.
• A curriculum vitae setting out your educational qualifications as well as any additional scientific achievements and publications.
• Evidence of English proficiency – for more details please see: https://www.ucl.ac.uk/prospective-students/graduate/english-language-requirements
• Copy of Bachelor’s and Master’s certificates (if available at the time of application).
• Copy of Bachelor’s and Master’s transcripts.
• Two letters of recommendation from researchers familiar with your academic activities, e.g. the advisor of your Master’s thesis

To apply for the vacancy please click on the ‘Apply Now’ button below. For informal enquiries please contact Professor Alethea Tabor [email protected] Queries on the application process can be directed to H Dansey [email protected], as we wish to encourage online applications.The salary ranges from £35,159 – £46,759 per annum, depending on circumstances.About you The successful candidate will have a Masters degree in Chemistry, Chemical Biology, Medicinal Chemistry, Natural Sciences or similar subject at the time of starting the post. They will have a passion for high quality interdisciplinary research and enthusiasm and interest in organic chemistry and chemical biology. Experience in organic synthesis, purification and characterization is required. Expertise in solid phase peptide synthesis is desirable but not essential, as full training will be provided. During the three years, the researcher will also undertake three research/training placements at partners within the MC4DD network: Uppsala University, Sweden (NMR); Sanofi, Germany (molecular modelling); Leiden University, Netherlands (library screening). There will be a high degree of interaction with other partners within the Doctoral Training Network. Excellent team-working and communication skills, and a keen interest in interdisciplinary research at the chemical biology/structural biology/computational biology interface will be required. To be eligible for the post you must not have resided or carried out your main activity (work, studies) in the UK for more than 12 months prior to the recruitment date.Available documents

Expected salary

£35159 – 46759 per year

Location

North West London

Job date

Sat, 27 Jul 2024 23:33:13 GMT

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