Doctoral (PhD) student position: Exploring the role of the bone marrow microenvironment in low-risk myelodysplastic syndromes

We’re recruiting a doctoral (PhD) scholar. To be a doctoral scholar means to dedicate oneself to a analysis undertaking below supervision of skilled researchers and following a person examine plan. For a doctoral diploma, the equal of 4 years of full-time doctoral schooling is required.

The Division of Drugs, Huddinge

The Division of Drugs, Huddinge performed preclinical and medical analysis in quite a lot of areas and undergraduate and graduate schooling. The division is internationally oriented and consists of seven items with about 40 groups.

The analysis group

The Hellström-Lindberg group’s  analysis focus is on mobile and molecular pathways underlying aberrant stem cell operate and ineffective erythropoiesis in myelodysplastic syndromes (MDS). Latest research from our group on this topic embody Moura, et al., Most cancers Analysis 2023; Todisco, et al., Medical Most cancers Analysis 2023; Hofman, et al., Blood Advances 2022; Elvarsdottir, et al., Leukemia 2020; Shiozawa, et al., Blood 2017; Mortera Blanco, et al., Blood 2017. We’re exploring MDS pathogenesis alongside two strains: to know the aggressive benefit of SF3B1 mutated stem cells within the human bone marrow area of interest, and to stipulate the mechanisms behind terminal erythroid failure. That is studied in major affected person samples from our MDS biobank via numerous applied sciences similar to superior stream cytometry, high-throughput RNA sequencing together with single cell evaluation, and numerous in vitro and in vivo stem cell assays.

The undertaking will happen throughout the body of a significant collaborative analysis grant and a big private grant from the Wallenberg Basis. The undertaking will likely be pursued at HERM .

The doctoral scholar undertaking and the duties of the doctoral scholar

Myelodysplastic syndromes (MDS) comprise a broad spectrum of hematological malignancies affecting the hematopoietic stem cell compartment and inflicting myeloid cytopenias. The low-risk subset of illness in myelodysplastic syndromes has the next survival price than median however usually presents extreme cytopenias with with restricted remedy choices.

The research on this undertaking will functionally examine bone marrow (BM) cell subsets and the worldwide structure of the low-risk MDS BM microenvironment to additional the sphere’s understanding of MDS, and have the last word purpose of uncovering novel essential regulatory mechanisms in MDS.

What do we provide?

A inventive and provoking atmosphere full of experience and curiosity. Karolinska Institutet is among the world’s main medical universities. Our imaginative and prescient is to pursue the event of information about life and to advertise a greater well being for all. At Karolinska Institutet, we conduct profitable medical analysis and maintain the most important vary of medical schooling in Sweden. As a doctoral scholar you might be provided a person analysis undertaking, a well-educated supervisor, an enormous vary of elective programs and the chance to work in a number one analysis group. Karolinska Institutet collaborates with outstanding universities from all around the globe, which ensures alternatives for worldwide exchanges. You’ll be employed on a doctoral studentship which implies that you obtain a contractual wage. Staff even have entry to our fashionable fitness center free of charge and obtain reimbursements for medical care.

Eligibility necessities for doctoral schooling

With the intention to take part within the choice for a doctoral place, you could meet the next normal (A) and particular (B) eligibility necessities at newest by the applying deadline.

It’s your accountability to certify eligibility by following the directions on the net web page Entry necessities (eligibility) for doctoral schooling.

A) Basic eligibility requirement

You meet the overall eligibility requirement for doctoral/third-cycle/PhD schooling should you:

have been awarded a second-cycle/superior/grasp qualification (i.e. grasp diploma), or

have glad the necessities for programs comprising a minimum of 240 credit of which a minimum of 60 credit have been awarded within the superior/second-cycle/grasp stage, or

have acquired considerably equal data in another method in Sweden or overseas.*

Observe the directions on the net web page Entry necessities (eligibility) for doctoral schooling.

*When you declare equal data, observe the directions on the net web page Assessing equal data for normal eligibility for doctoral schooling.

B) Particular eligibility requirement

You meet the particular eligibility requirement for doctoral/third-cycle/PhD schooling should you:

– Present proficiency in English equal to the course English B/English 6 at Swedish higher secondary college.

Observe the directions on the net web page English language necessities for doctoral schooling.

Verification of your paperwork Karolinska Institutet checks the authenticity of your paperwork. Karolinska Institutet reserves the suitable to revoke admission if supporting paperwork are found to be fraudulent. Submission of false paperwork is a violation of Swedish legislation and is taken into account grounds for authorized motion.

(A) and (B)can solely be licensed by the documentation requirement for doctoral schooling .

Abilities and private qualities

Candidates ought to have a minimum of a grasp’s diploma in medication, molecular biology or immunology. Candidates with a mixed background protecting medication, biology, math and programming are extremely inspired to use. Bioinformatic expertise utilizing R will likely be appeared upon favorably. Equally, earlier expertise with single cell RNA sequencing, stream cytometry for evaluation of major hematopoietic cells, and immunofluorescence imaging strategies will likely be appeared upon positively. Applicant ought to be fluent in English (written and spoken). Emphasis will likely be positioned on private suitability.

Phrases and circumstances

The doctoral scholar will likely be employed on a doctoral studentship most 4 years full-time.

Software course of

Submit your software and supporting paperwork via the Varbi recruitment system. Use the button within the prime proper nook and observe the directions. We desire that your software is written in English, however you can too apply in Swedish.

Your software should comprise the next paperwork:

– A private letter and a curriculum vitae
– Diploma tasks and former publications, if any
– Some other documentation displaying the fascinating expertise and private qualities described above
– Paperwork certifying your normal eligibility (see A above)
– Paperwork certifying your particular eligibility (see B above)

Choice

A range will likely be made amongst eligible candidates on the premise of the flexibility to profit from doctoral schooling. The {qualifications} of the candidates will likely be evaluated on an general foundation.

Karolinska Institutet makes use of the next bases of evaluation:

– Documented topic data of relevance to the realm of analysis
– Analytical talent
– Different documented data or expertise that could be related to doctoral research within the topic.

All candidates will likely be knowledgeable when the recruitment is accomplished.

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