As survival rates for complex metastatic cancer rise, there is increasing demand to measure multiple functional biomarkers of tumour heterogeneity and treatment response throughout the entire body. Using the soon to be installed Biograph Vision Quadra™ Total-Body-PET/CT scanner at St Thomas’ Hospital (part of the National Total-Body-PET Imaging Programme, NPIP) this project will develop novel tracer imaging strategies for organ-specific kinetic analysis with a variety of clinical tracers. Simultaneous measurement at all cancer sites and in all organs will provide high temporal resolution data of clinically relevant kinetic parameters to characterise tumours and monitor treatment effects. Initially, focus will be on mono-tracer studies in cancer patients with disease at a few sites, expanding to widespread disease and then multi-tracer imaging. Multiparametric imaging data will be combined with clinically available datasets to build predictive deep learning / AI models that comprehensively phenotype cancer and assist prognostication, aiding more effective treatment for advanced cancer.
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