Genomic Precision Medicine Specialist – Rare Diseases

Job title:

Genomic Precision Medicine Specialist – Rare Diseases

Company

Novo Nordisk

Job description

The PositionWe are looking for a highly qualified and innovative Specialist in Genetics, to implement cutting-edge human genetics insights to answer questions that will improve trial success and support human-genetics driven precision medicine for Rare Disease.In this role you will:

• Provide human genetic support to project teams responsible for the progression of given therapies through the drug pipeline,
• Work closely with colleagues to identify areas where genetics can help guide decision making e.g. indication selection, target population identification, adverse effects,
• Use genetic data with other omics – proteomics, metabolomics, transcriptomics and epigenetics – to better understand and personalize treatment responses,
• Have the opportunity to incorporate trial data with genetics to inform decision making and identify populations that will respond best to the treatments developed by our scientists.

You will be expected to develop and drive your own projects, while also providing your expertise to existing projects within the Human Genetics Centre of Excellence (CoE) in Oxford/London/Copenhagen. Our research centre is a collaborative endeavour, and you will work alongside statistical geneticists, clinicians, and computational and laboratory scientists from across the organisation and with external collaborators, to help get the right treatment to the right patient.We offer a hybrid working model with 3 days from one of our offices – London, Oxford (UK), or Copenhagen (Denmark).QualificationsWe welcome candidates with a good team ethic, who pay close attention to detail, enjoy a fast paced, dynamic environment where creative intellectual independence and knowledge sharing is actively encouraged. Most importantly, you must have a strong interest in applying your skills in the field of drug development.We are particularly interested in hearing from candidates with human genetics knowledge applied in a drug discovery or development setting to enhance our precision medicine efforts.Moreover, we expect our candidate to:

• Hold a Ph.D. in human genetics, statistical genetics, genetic epidemiology, pharmacogenomics or other related fields, and have made significant contributions to high-impact scientific publications.
• Have several years post PhD experience in the genetics of rare diseases – ideally rare blood and/or endocrine disorders (Sickle cell, Haemophilia, Growth Disorders).
• Possess knowledge of, and experience with high performance computing systems and with using programming languages, for analysis of large-scale datasets, e.g., R, Python, or similar.
• Have some years of experience with large-scale genetic datasets and GWAS (including marker-trait and gene-trait associations).
• Have experience of communicating insights and presenting concepts to a diverse audience.
• Be self-driven and work well in interdisciplinary teams.

Having previous experience in handling omics data (e.g. transcriptomics, proteomics) would be considered an advantage and so would professional/post doc experience in handling and analysing clinical trial data in academia or preferably biotech/pharma industry.About the DepartmentYou will be a member of our Translational Genomics & Precision Medicine Department which is part of the Human Genetics Centre of Excellence (CoE) led by Vice President, Joanna Howson PhD. The focus of the CoE is to use data science and human genetics to discover and develop new drug targets and biomarkers through a range of human centric approaches e.g., high-through put genetic discovery screens; Mendelian randomization; pLoF variant screens and precision medicine approaches relevant to type 2 diabetes, chronic kidney disease, CVD, non-alcoholic steatohepatitis (NASH), obesity and rare endocrine and blood disorders.The CoE is anchored in the newly established Digital Science & Innovation (DSI) organisation within Research & Early Development at Novo Nordisk. DSI is supporting the digital journey across all our therapy areas in R&ED. In DSI, we work in multidisciplinary teams in strong collaboration with all areas across R&ED and R&ED IT. We participate in drug development projects across the value chain, from early discovery to pre-clinical development. We engage in external collaborations to ensure access to the latest research and technology enablers, and we automate our labs and processes, and we focus on developing and retaining top talent.Working at Novo NordiskWe are a proud life-science company, and life is our reason to exist. We’re inspired by life in all its forms and shapes, ups and downs, opportunities and challenges. For employees at Novo Nordisk, life means many things – from the building blocks of life that form the basis of ground-breaking scientific research, to our rich personal lives that motivate and energise us to perform our best at work. Ultimately, life is why we’re all here – to ensure that people can lead a life independent of chronic disease.ContactPlease apply to the role by submitting your application through our careers site, as we do not accept directly sent resumes.DeadlinePlease apply before 31st August 2024.We encourage you to apply early as we start engaging with candidates on an ongoing basis!We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

Expected salary

Location

London

Job date

Mon, 12 Aug 2024 22:54:17 GMT

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