GMP Stem Cell Scientist

Job id: 086611. Wage: £32,979 – £35,487 each year, together with London Weighting Allowance.

Posted: 20 March 2024. Cut-off date: 10 April 2024.

Enterprise unit: School of Life Sciences & Medication. Division: Gene Remedy and Regenerative Medication.

Contact particulars:Heather Kneale. [email protected]

Location: Man’s Campus. Class: Skilled & Assist Providers.

Job Description

Function goal

The Ocular Cell and Gene Remedy group (OCGT), within the Centre for Gene Remedy and Regenerative Medication (CGTRM), develops all kinds of novel cell and gene therapies for the therapy of neurodegenerative illnesses, with a selected emphasis on retinal illness.

That is an thrilling alternative to work on the interface of primary and scientific analysis in a bunch that’s on the forefront of growing novel therapies for retinal problems, with a significant emphasis on translating analysis into scientific utility. Led by Professors Robin Ali and Rachael Pearson (beforehand at UCL’s Institute of Ophthalmology), it is likely one of the largest mobile remedy teams within the nation and is at present increasing. Over the previous 20 years, the group has been optimising cell transplantation to the attention to develop novel therapeutic approaches for eye illness and particularly for problems affecting the retina, together with inherited retinal degeneration. The programme has already led to first-in-human scientific trials of gene and cell remedy for eye illness and we are actually within the pre-clinical improvement section for scientific trials for photoreceptor cell remedy.

Function profile

As a part of the position profile, the profitable candidate shall be required to take part in actions associated to stem cell tradition, protocol improvement, facility and tools upkeep, digital report documentation. They are going to help pre-clinical R&D involving human stem cell derived retinal cells and assist transition pre-clinical protocol course of improvement in the direction of GMP compliance.

The work will embody day-to-day operations and execution of improvement and manufacturing runs, serving to to co-ordinate the technical workforce and make sure the schedule is adopted by collaborating in improvement, validation and manufacturing processes, liaising with the standard and technical groups, getting ready documentation, figuring out bottlenecks and reporting to Senior Administration.

We’re searching for a extremely motivated particular person who’s excited by working with stem cells and growing GMP-compliant manufacturing protocols. A organic background and former expertise of human cell tradition and dealing to GMP circumstances are extremely fascinating, however not important. The best candidate could have glorious organisational abilities and a spotlight to element. The candidate ought to perceive and be skilled in house-keeping actions together with medium preparation, sterilisation in autoclave, tools calibration, upkeep, decontamination, environmental monitoring and routine operations to make sure cGMP compliance. Expertise in MS Workplace pc abilities is crucial to create, entry and submit experiences for evaluate and approval.

Additional, the submit holder could also be required to take an energetic position in different tasks throughout the Ocular Cell and Gene Remedy Group, as required by supervisor or head. This can be a distinctive alternative to work in a vibrant translational analysis atmosphere. The submit holder will work in a collaborative workforce atmosphere with very excessive potential to be taught new abilities.

This submit shall be provided on a fixed-term contract for twenty-four months.

This can be a full-time submit – 100% full time equal

Key Duties

Key Aims:

• Carry out operations associated to stem cell manufacturing as an energetic member of OCGT engaged on the event of stem cell-based therapies.
• Exhibit a dedication to ongoing skilled improvement and interact in and endure related coaching, together with hands-on operations associated to aseptic strategies, stem cell tradition, cell sorting, GMP course of, as required.
• Replace information and understanding within the subject of cell remedy.
• Professional-actively help the GMP manufacturing and QC groups within the clean transition of pre-clinical to GMP manufacturing.
• Help and help different members of the group, utilizing a scientific and well timed strategy to resolve issues, whereas dealing with a number of tasks.
• Present cowl within the absence of key manufacturing workers.
• Handle personal workload and sources based mostly on an agreed work plan for achievement of challenge goals while additionally being conscious of altering priorities.
• Use information evaluation abilities to analyse and interpret analysis information and draw conclusions on the outcomes 
• Full and submit up-to-date, correct and complete documentation information and laboratory experiences, the place relevant.
• Attend and contribute to workforce conferences for periodic evaluate and progress.
• Full assigned duties in collaboration with different members of the broader workforce together with Preclinical Analysis, GMP manufacturing, QC and Course of Improvement groups, as required.
• Forge relationships with colleagues within the college and externally, to construct relationships, disseminate and get data, coordinate, and ship the service.
• Help within the coaching of recent workers, the place applicable.
• Work to assist the implementation of environmentally sustainable practices, recording progress by means of the King’s sustainability audit course of and sharing good observe. 
• Facilitate an inclusive tradition and ethos working with tutorial, analysis and different skilled providers workers and colleagues exterior to King’s. 

The above listing of tasks is probably not exhaustive, and the submit holder shall be required to undertake such duties and tasks as could fairly be anticipated throughout the scope and grading of the submit.

A extra complete overview of the important thing tasks could also be requested from Heather Kneale –[email protected]

Abilities, information, and expertise

Important standards

{Qualifications} and Coaching

Minimal degree 3 qualification, e.g. A ranges, AS ranges, Worldwide Baccalaureate diploma or different Degree 3 qualification, plus work expertise in related technical/scientific posts OR Appreciable information and abilities gained by means of work expertise in related technical or scientific posts. 

Proof of an energetic dedication to profession improvement, akin to skilled registration with related organisations, present process sensible, on the job coaching inside a life sciences laboratory &/or clear development in more and more demanding jobs.

Background in stem cell dealing with, and hands-on expertise in aseptic dealing with, mobile and molecular strategies (AP, I) 

Abilities / Expertise

Expertise in commonplace molecular and cell biology strategies (e.g. cell tradition, RT-PCR, histology, immunocytochemistry, cell splitting/dissociating).  

Expertise in helping with the each day upkeep duties concerned in a busy lab, together with report protecting, inventory checking and ordering, tools upkeep and cleansing and serving to to plan cell tradition rotas (AP, I).  

Data 

Understanding of cell remedy, bioprocessing &/or GLP/GMP manufacturing (AP, I) 

Competencies 

Expertise in related aseptic and molecular and mobile strategies, (e.g. cell tradition, RT-PCR, histology, immunocytochemistry, cell splitting/dissociating) (AP, I). 

Wonderful organisation and report protecting abilities and competency in finishing and dealing with digital or paper-based laboratory documentation, experiences and information (AP, I). 

Clear spoken and written communication abilities, glorious report protecting and a spotlight to element, capacity to work with and contribute to the workforce success offering scientific enter throughout conferences and protecting a wholesome working ambiance within the lab (AP, I). 

Willingness and skill to work exterior core hours (AP, I) 

Fascinating standards 

Palms on expertise of working with human stem cell cultures 

Competency in aseptic method 

Expertise of working to GLP/GMP requirements. 

Expertise of movement cytometry