Investigator, Protein Expression and Purification

Job title:

Investigator, Protein Expression and Purification

Company

GlaxoSmithKline

Job description

Investigator, Protein Expression and PurificationLarge Molecule Discovery (LMD) is dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation, to molecular engineering and biological and physiochemical profiling.The Antibody Protein Sciences group in LMD takes accountability expression and characterisation of panels of antibody molecules from early Hit-Panels through to optimised engineered molecules for developability profiling prior to candidate selection. We have recently invested in automation to increase our capacity to meet increased demand and have now deployed these world-leading systems onto our drug discovery pipeline. We are seeking an experienced enthusiastic, dynamic and self-motivated lab-based scientist to join us in creating the medicines of the future.This role would suit an inquisitive scientist highly skilled in mammalian cell transfection, culture and protein biochemistry. You will be involved in the use of novel automation solutions, so experience with and/or enthusiasm for the use of automation would be an advantage.We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageIn this role you will

• Demonstrate scientific leadership and pipeline impact through a lab-based role
• Generate stable cell lines and conduct transient transfections (cell maintenance, quality control of cell culture; transfection)
• Perform protein purification using affinity and ion-exchange techniques
• Design, execute and troubleshoot workflows using Tecan-based automated liquid handling systems
• Design, perform and write up high quality scientific experiments in a timely manner
• Influence scientific direction and execution of projects and discovery platforms in the group

Why you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:

• PhD or equivalent experience in biochemical engineering, cell biology, bioprocessing or a related discipline
• Experience of stable cell line generation and transient transfection (cell maintenance, quality control of cell culture; transfection)
• Experienced in protein purification strategies
• Demonstrable ability to lead impactful projects, identify and troubleshoot problems in the execution of experiments and support other team members
• Good attention to detail in experimental setup, reporting/writing up data and verbal presentation
• Demonstrated ability to work effectively in multi-disciplinary teams and display excellent interpersonal and communication skills

Preferred Qualifications & Skills:Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Expertise in the use and troubleshooting of automated LiHa (in particular Tecan and Akta systems)
• Capable of performing complex data management and data interpretation tasks/analyses
• Troubleshooting and critique of process workflows

• Track record of building collaborations internally and/or externally
• Scientific leadership skills with experience of authoring publications in peer reviewed journals

Closing Date for Applications: 8th October 2024Please take a copy of the Job Description, as this will not be available post closure of the advert.When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Fri, 27 Sep 2024 00:38:26 GMT

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