Investigator Scientist

Job title:

Investigator Scientist

Firm

MRC Laboratory of Molecular Biology

Job description

To work throughout the group of Dr Greg Jefferis on the LMB in collaboration with Dr Joseph Collin at AstraZeneca on a mission aimed toward understanding gene applications driving neuronal range and wiring specificity rising from the connectome. The profitable candidate will start work on a lately acquired scRNAseq dataset of the growing fly nerve wire. This has unprecedented mobile protection (~ 10x oversampling), which might be additional expanded in the middle of the mission. Pilot evaluation has already revealed a extremely structured organisation of neurons within the dataset based on their start origin, offering a direct hyperlink to the ventral nerve wire connectome (https://www.biorxiv.org/content material/10.1101/2023.06.05.543407v1). This affords the likelihood to take a divide and conquer method to match two very complicated however foundational Omics datasets. Linking the developmental transcriptome and connectome will lay the foundations for molecular connectomics, with long-term implications for the examine of circuit perform, improvement and illness.Primary duties:

• Beneath the final management of the Group Chief, to be answerable for all points of the analysis tasks, together with defining the route of the work, conducting the analysis, analysing the information, getting ready the work for publication and disseminating the outcomes at conferences.
• Develop computational instruments to combine scRNAseq datasets from completely different developmental timepoints.
• Mannequin cell kind identities alongside developmental trajectories for particular person stem cells, integrating exact information of cell kind composition derived from the connectome.
• Take part in gathering new scRNAseq knowledge at AZ (Cambridge) to a) use molecular barcoding to disclose start timing throughout the transcriptomic knowledge construction and b) scale research from the nerve wire (~25,000 neurons) to the mind (~135,000 neurons)
• Work together with the AZ crew in Gothenburg (Sweden) led by Joseph Collin, which can embrace web site visits and quick stays for coaching and evaluation functions.
• To contribute to laboratory-wide discussions on developments throughout the laboratory, notably in using new methods or new gear.
• To establish, develop and apply a broad vary of methods to pursue the analysis targets together with by working in collaboration with others to realize joint analysis tasks.
• To maintain updated with developments within the subject, proposing or implementing modifications of route as vital.
• To arrange the analysis for publication.
• To current your work at seminars throughout the laboratory and at exterior conferences.
• To coach college students, Postdoctoral Scientists and others and undertake the road administration of group members the place acceptable.
• To contribute to the MRC’s engagement with the general public and within the translation of analysis findings into enhancements in well being care.

Key obligations:The important thing accountability is to undertake cutting-edge analysis, aimed toward key questions throughout the remit of the analysis group. You can be anticipated to supply the mental vitality and unbiased considering essential to ship the analysis and to play a serious function in shaping the general goals and success of the group.Whereas some recommendation might be out there from others within the laboratory, you may be anticipated to have the ability and understanding to have the ability to act independently in fixing issues, a lot of which can require novel approaches. This may require the combination of various actions to make sure the profitable supply of the analysis tasks.To introduce and apply new methods throughout a variety of disciplines and to have the creativity and initiative to develop novel approaches.To work together successfully with a variety of employees, college students and others to make sure the sleek working of the analysis group. This may embrace setting an instance within the efficient use of assets, coaching others in strategies and use of kit and taking accountability for using communal amenities.To probably tackle particular obligations for managing gear.To write down scientific papers and to current at inside conferences and at conferences.To make sure the analysis is carried out in accordance with good follow and in compliance with native insurance policies and authorized necessities.To recognise alternatives for the creation of mental property and to cooperate in patent safety and in exploitation.To establish new gear which can help the group programme and to current argued circumstances for brand new purchases.To establish alternatives for extra funding and to use for exterior grants the place acceptable.The place line administration obligations are undertaken, these obligations, together with employees improvement and efficiency administration, must be utilized in accordance with the MRC’s insurance policies and procedures. Coaching might be supplied if required.Working relationships:You’ll report back to Dr Greg Jefferis and can liaise with senior scientists, together with Dr Sebastian Cachero, and college students in your group, throughout the LMB and with exterior collaborators at AstraZeneca and the CNR, Milan.Equality & RangeUKRI values the varied expertise and expertise of its staff and is dedicated to attaining equality of remedy for all. Our targets are that each one people shall have equal alternatives for employment and development on the premise of their expertise, aptitudes and skills. UKRI is dedicated to the engagement and retention of the absolute best expertise and to creating an atmosphere that encourages excellence in scientific analysis via good equalities and variety management and administration.Company/Native obligations & necessitiesYou need to always perform your obligations with due regard to the UKRI:

• Code of Conduct
• Equality, Range and Inclusion coverage
• Well being and Security coverage
• Information Safety coverage

Job descriptions must be reviewed frequently and on the annual appraisal. Any modifications must be made and agreed between you and your supervisor.The above lists will not be exhaustive and you’re required to undertake such duties as could moderately be requested throughout the scope of the publish. All staff are required to behave professionally, co-operatively and flexibly according to the necessities of the publish, the MRC and UKRI.The function holder might be required to have the suitable stage of safety screening/vetting required for the function. UKRI reserves the precise to run or re-run safety clearance as required in the course of the course of employment.Individual necessitiesTutorial {qualifications} and expertise:PhD in a related topic or masters in a related topic and important analysis expertise in bioinformatics.Vital doctoral or postdoctoral analysis expertise in Bioinformatics, Pc Science, AI or related subject.Technical expertise and experience:Expertise of and confirmed skill to carry out methods related to the mission, and information of the sector. Significantly helpful can be expertise of:

• Coding in R and/or Python.
• Expertise with not less than one in all:

• Single-cell transcriptomics knowledge evaluation
• Machine studying

Expertise with software program/open science greatest practices (fascinating). * Neuroscience/improvement/Drosophila genetics/dissections/molecular biology (not important)Monitor file of analysis:This may embrace achievements, and important contributions to revealed papers.Different related proof of:

• Dedication.
• Originality.
• Potential to speak.
• Working with others.

Anticipated wage

Location

Cambridge – London

Job date

Tue, 19 Mar 2024 23:19:39 GMT

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