Lead Cell-Based Therapeutics Technician

Employees – Non Union

Job Class
Non Union Technicians and Analysis Assistants

Job Profile
Non Union Salaried – Analysis Assistant /Technician 4

Job Title
Lead Cell-Based mostly Therapeutics Technician

Division
Levings Laboratory Childhood Illnesses BC Kids’s Hospital Analysis Institute College of Medication

Compensation Vary
$5,068.91 – $5,946.08 CAD Month-to-month

Posting Finish Date
February 9, 2024

Observe: Functions shall be accepted till 11:59 PM on the day previous to the Posting Finish Date above.

Job Finish Date

Feb 28, 2025

This place is situated inside a health-care facility, subsequently, the profitable candidate shall be required to supply verification of full vaccination towards Covid-19 offered previous to the beginning date, as required by a provincial well being mandate.

​This place is conditional upon profitable completion of a Felony Document Verify.
 

This place is predicted to be stuffed by promotion/reassignment and is included right here to tell you of its emptiness on the College.

JOB SUMMARY

The lead cell-based therapeutics technician is answerable for coaching, organizing, main, and designing in vitro and in vivo fashions for the use and advantage of a analysis laboratory closely based mostly in cell remedy analysis. The lead technician requires specialised data of each immunology and cell engineering to work collaboratively with each trainees and workers to evaluate the efficacy of the potential cell product. This place entails the designing, executing, analyzing, and presenting of outcomes of complicated useful in vitro cell assays and establishing applicable animal fashions for in vivo pre-clinical testing. The incumbent assists in reporting again to funding businesses and finishing required regulatory documentation. This place can also be answerable for coaching and offering path for key duties to workers and college students.

ORGANIZATIONAL STATUS

The UBC College of Medication Division of Surgical procedure educates college students on the undergraduate, graduate and postgraduate ranges, and pursues analysis to make progressive developments in data and follow to enhance well being. The Division consists of greater than 600 physicians, surgeons, scientists and educators and over 70 administrative, analysis and technical workers in 9 divisions distributed throughout British Columbia. Specialty coaching packages are supplied in Cardiac Surgical procedure, Basic Surgical procedure, Colorectal Surgical procedure, Neurosurgery, Otolaryngology, Pediatric Surgical procedure, Plastic Surgical procedure, Radiation Oncology, Thoracic Surgical procedure and Vascular Surgical procedure. The Division can also be house to the Department for International Surgical Care (BGSC).

The lead cell-based therapeutics technician studies on to the Principal Investigator, Dr. Megan Levings. The incumbent interacts intently with members of Dr. Levings’ laboratory in addition to these in different laboratories at BCCHR on the BC Kids’s Hospital campus and workers within the UBC Division of Surgical procedure.

WORK PERFORMED

Design, execute, and analyze a wide range of useful immune cell based mostly assays. Modify cell merchandise to be conductive for cell remedy. Strategies embody retroviral and lentiviral transduction and CRISPR gene enhancing. Develop and optimize protocols and customary working procedures (SOPs) for creating useful analysis assays to repeatedly enhance lab analysis and introduce new methods Keep the lab’s animal colonies, guaranteeing the colonies are in good well being and quantity, and that related animal care protocols shall be saved updated. The technician is answerable for monitoring and coaching of lab trainees and workers to make sure animal care requirements are adhered to. Lead, oversee, and carry out procedures on stay mice for long run in vivo research. Experimental mouse monitoring shall be performed in keeping with animal protocols, together with well being monitoring, taking blood and tissue samples, surgical procedures, and cell based mostly interventions. Prepare and information different laboratory workers and college students within the above procedures, significantly for assay improvement and animal dealing with methods Talk successfully with BCCHR and UBC officers, committees, and ethics boards concerning the creation of latest or amended animal protocols.  Put together detailed studies on experimental outcomes, current information and outcomes to different lab members, the Principal Investigator, exterior collaborators and funding businesses. Information generated shall be utilized for studies and future grant functions. Analysis and decide the applicability and feasibility of latest assays, know-how, and animal fashions associated to the lab’s analysis space. Help with laboratory upkeep duties, together with the overall group and maintenance of the laboratory, and guarantee security and moral analysis requirements are maintained and adopted. Keep data of labor carried out for documentation in keeping with laboratory requirements. Contributes to a respectful, inclusive working surroundings. Carry out different associated duties as required.

WORKING CONDITIONS

The work shall be carried out totally on the 4th ground in an open-concept analysis laboratory on the BCCHR Translational Analysis Constructing. Chemical fume hoods, tissue tradition amenities, freezers, fridges, bench prime tools, core amenities and security gadgets (eyewash, bathe, fireplace extinguishers, spill and first assist kits) are situated within the lab or throughout the BCCHR. Animal work shall be performed within the Animal Care Facility at BCCHR.

CONSEQUENCE OF ERROR/JUDGEMENT

The incumbent is predicted to work below restricted supervision and train judgment in addition to discretion and tact along with displaying initiative in duties and tasks. The incumbent wants to concentrate to particulars, pay attention to pitfalls and keen to repeat duties if essential. Some procedures contain following protocols already in place; nonetheless, there will even be protocol improvement which can require progressive considering and literature analysis. Enter into the path of analysis initiatives is inspired. Errors in judgment might end in inadequate progress of analysis initiatives, thereby adversely affecting funding for research. Inappropriate dealing with of interactions and communications can create embarrassment for the Lab and Division in dealings with college, college students, College, affiliated hospitals, sufferers, enterprise associates, and the general public.

SUPERVISION RECEIVED

The Principal Investigator, Dr. Megan Levings offers total supervision of this position, nonetheless, the incumbent might take path and suggestions from senior members of the laboratory.

SUPERVISION GIVEN

None.

MINIMUM QUALIFICATIONS

• Completion of a college diploma in a related self-discipline or technical program and a minimal 4 years of associated expertise or an equal mixture of schooling and expertise.

• Willingness to respect various views, together with views in battle with one’s personal.

• Demonstrates a dedication to enhancing one’s personal consciousness, data, and expertise associated to fairness, range, and inclusion.

PREFERRED QUALIFICATIONS

• Intensive expertise in immune cell tradition, significantly with typical and regulatory T cells.

• Intensive expertise and data in immunology and cell biology, together with up-to-date methods on cell isolation, growth and differentiation, gene enhancing/modification, and related useful assays.

• Expertise in modifying, performing and trouble-shooting complicated immunological experiments utilizing a wide range of in vivo or in vitro techniques.

• Nicely versed in move cytometry, together with proficiency in color compensation, complicated multi-colour panel design, working with various kinds of move cytometers, and is proficient utilizing move information evaluation packages, reminiscent of FlowJo.

• Expertise working with viruses in a degree 2+ facility requiring enhanced security procedures.

• Educated and authorized in animal dealing with and better degree methods, reminiscent of injections and blood attracts.

• Efficient interpersonal and organizational expertise. 

• Capable of talk concepts effectively and successfully to a wide range of audiences.

• Capacity to work successfully each independently and inside a staff surroundings. 

• Capacity to contribute to a respectful, cooperative and supportive work surroundings.

• Capacity to work a versatile schedule and extra hours sometimes on weekends, evenings and early mornings, as required.