Medicine: Swansea University Research Excellence Scholarships (SURES): Fully Funded PhD Scholarship: The in vivo mechanistic dissection of lifespan extension pathways using senolytic compounds in the African Turquoise Killifish model of ageing

Job title:

Medicine: Swansea University Research Excellence Scholarships (SURES): Fully Funded PhD Scholarship: The in vivo mechanistic dissection of lifespan extension pathways using senolytic compounds in the African Turquoise Killifish model of ageing

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Job description

Offer DescriptionFunding provider: Swansea UniversitySubject areas: Senolytics and ageingProject start date:

• 1 October 2024 (Enrolment open from mid-September)

Supervisors:

• Dr James T. Murray (Swansea University –

) * Professor Richard Faragher (Brighton University)Aligned programme of study: PhD in Gerontology and Ageing Studies (Regenerative Medicine)Mode of study: Full-timeProject description:Swansea University is pleased to offer fully-funded Swansea University Research Excellence Scholarships (SURES) for full-time doctoral students to its fifth cohort, commencing in October 2024.Ageing is a growing fundamental economic and social challenge since the age structure of our population will change markedly during this century. Despite significant improvements in living conditions and healthcare leading to increasing life expectancy, it is extremely rare to grow old in good health and by the age of 85 essentially no individual is disease-free. As such, drug discovery research is focusing on potential interventions that enhance the human health span. One area of research focus is on the reversal of cellular senescence, and so there has been a rapid development of interventions that behave as senolytic drugs. One such drug is Resveratrol, a naturally occurring plant compound that is thought to reverse cellular senescence through its action on SIRT1.The specific aim of the project is to use Resveratrol, and related senolytic compounds, to identify ageing pathways in a new in vivo model of ageing the African Turquoise Killifish (Nothobranchius furzeri). The project will investigate the effect of mid-lifespan dosing of Resveratrol and similar compounds on lifespan and ageing (senescence) markers in Killifish using RNA-seq and proteomic approaches. Once novel pathways are identified, the project will then use gene editing (CRISPR/Cas9) of Killifish to validate these novel mechanisms of senescence reversal.This project will be a collaboration between the Murray laboratory at Swansea University, and the Faragher laboratory, at the University of Brighton.RequirementsResearch Field Medical sciences Education Level Bachelor Degree or equivalentSkills/QualificationsCandidates must have attained, or must be expected to attain, a first-class honours degree and/or a distinction at master’s level. If you are eligible to apply for the scholarship but do not hold a UK degree, you can check our comparison entry requirements. Please note that you may need to provide evidence of your English Language proficiency.

• Where applicants have multiple master’s degrees, a distinction must be held in the degree that is most relevant to the intended PhD study.
• If you are currently studying for a master’s level qualification with an expected award date that is later than 01/10/2024, you should hold a minimum of an upper-second-class (2:1) honours degree.
• You should be able to demonstrate a pass with a minimum grade average of at least 70% for your part-one master’s degree modules (the taught aspect of your master’s course rather than a research-focused dissertation) and submit your dissertation by no later than 30/09/2024.

Specific RequirementsApplicants must be able to begin their course of study in October 2024. As a cohort-based programme, deferral to an alternative enrolment window within the academic year or to another academic year is not permissible.Please note that both the degree and language-proficiency entry requirements for SURES are higher than the baseline standard for entry that is stipulated for most of the PhD programmes at Swansea University.Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by .Additional InformationBenefitsThis scholarship covers the full cost of UK tuition fees and an annual stipend at £19,237.Additional research expenses will also be available.Eligibility criteriaCandidates must have attained, or must be expected to attain, a first-class honours degree and/or a distinction at master’s level. If you are eligible to apply for the scholarship but do not hold a UK degree, you can check our comparison entry requirements. Please note that you may need to provide evidence of your English Language proficiency.

• Where applicants have multiple master’s degrees, a distinction must be held in the degree that is most relevant to the intended PhD study.
• If you are currently studying for a master’s level qualification with an expected award date that is later than 01/10/2024, you should hold a minimum of an upper-second-class (2:1) honours degree.
• You should be able to demonstrate a pass with a minimum grade average of at least 70% for your part-one master’s degree modules (the taught aspect of your master’s course rather than a research-focused dissertation) and submit your dissertation by no later than 30/09/2024.

Applicants must be able to begin their course of study in October 2024. As a cohort-based programme, deferral to an alternative enrolment window within the academic year or to another academic year is not permissible.Please note that both the degree and language-proficiency entry requirements for SURES are higher than the baseline standard for entry that is stipulated for most of the PhD programmes at Swansea University.Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by .Selection processPlease visit our website for more information.Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Swansea University Country United Kingdom GeofieldWhere to apply WebsiteContact State/ProvinceSwansea CitySwansea WebsiteStreetSingleton Park Postal CodeSA2 8PPSTATUS: EXPIRED

Expected salary

£19237 per year

Location

Swansea

Job date

Sun, 28 Apr 2024 04:20:25 GMT

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