PET QC Manager

Job title:

PET QC Manager

Company

King’s College London

Job description

The PET Centre is part of Guy’s & St Thomas’ NHS Foundation Trust and King’s College London within the School of Biomedical Engineering & Imaging Sciences.The Positron Emitting Radiopharmaceutical Laboratory (PERL) plays a crucial role in the clinical PET Centre, serving over 8,000 patients and research participants annually from South-East London and beyond. It is an integral part of both King’s College London’s School of Biomedical Engineering and Imaging Sciences and Guy’s & St Thomas’ National Health Service (NHS) Foundation Trust. Our PET Center relies heavily on the PERL facility for the supply of radiopharmaceuticals and this is likely to become increasingly important when the new Total Body PET scanner is installed later this year.Comprising two GMP clean rooms, a QC laboratory, and an R&D laboratory with a total of 24 hot cells, the PERL facility is equipped with a PETtrace high-energy cyclotron and various dispensing units, calibrators, and analysis equipment. It operates under a “Specials” manufacturing license, currently producing [18F]fluorodeoxyglucose (FDG) and [11C]methionine routinely, with ongoing development of additional radiotracers. We anticipate the availability of two more radiotracers for routine and research use by the end of 2024, with plans to expand the portfolio by two to three radiotracers annually.About the roleThe successful candidate will have overall responsibility for the QC analysis of PET radiotracers produced at the facility.This will include organising the routine analyses of radiopharmaceuticals, analytical methods development, documentation (SOPs, validation results, trending, etc.), overview of analytical infrastructure maintenance and building a proactive lab culture in the department; organising rotas for activities within QC; training of staff in QC-related activities and ensuring compliance with appropriate MHRA, radiation safety and other relevant legislation.The post-holder will take the lead in planning, preparation, data collection, monitoring, validation, documentation and implementation of QC methods, technology and instrumentation. The individual will also assist in the validation and implementation of new and established PET chemistry and PET radiotracer analyses for research and clinical use.The candidate must have PhD in chemistry or pharmacy or equivalent qualification, knowledge of PET and/or SPECT radiotracer synthesis, Ionising Radiation protection regulations and proven record in adhering to the principles of GLP and GMP.This is a full time post (35 Hours per week), and you will be offered an indefinite contract.About youTo be successful in this role, we are looking for candidates to have the following skills and experience:Essential criteria * PhD in chemistry or pharmacy or equivalent qualification or experience

• Radiochemistry/radiopharmacy research and development laboratory experience
• Practical experience of analytical chemistry techniques including HPLC and GC technology
• Demonstrable experience of operational GMP
• Knowledge of and proven record in adhering to the principles of GLP and GMP
• Word processing including internet and e-mail and ability to draft documents e.g. standard operating procedures (SOPs)
• Supervisory experience
• Excellent verbal and written communication skills

Desirable criteria * Membership of a professional body

• Experience with automated synthesis equipment
• Knowledge of PET and/or SPECT radiotracer synthesis
• Knowledge of Ionising Radiation protection regulations
• Experience with a range of radionuclides and with automated synthesis equipment

Downloading a copy of our Job DescriptionFull details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.Further informationThis post is subject to Disclosure and Barring Service and/or Occupational Health clearances.We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King’s.We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.Interviews are due to be held on 14th or 15th August 2024.We are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.CompanyKing’s College London is one of the top 20 universities in the world and among the oldest in England. King’s has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.King’s has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.King’s has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.King’s College London and Guy’s and St Thomas’, King’s College Hospital and South London and Maudsley NHS Foundation Trusts are part of King’s Health Partners. King’s Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world’s leading research-led universities and three of London’s most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: .King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at .Company info Mini-site Telephone +(44)02078365454 Location STRAND
LONDON
WC2R 2LS
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Expected salary

£51974 – 61021 per year

Location

Central London

Job date

Wed, 17 Jul 2024 22:42:24 GMT

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