The aim of this study is to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) in a series of related drug classes.
You will use the Medicines and Healthcare products Regulatory Authority (MHRA) Yellow Card drug analysis profiles (and other national and WHO databases) alongside NHS secondary care medicines databases to enable the identification of statistically significant suspected ADRs associated with a range of drug classes.
The polypharmacology of these drug classes will be data-mined from several public data sources to enable the interpretation of potential mechanistic reasons for these observed side effects.
Finally, a predictive model for new drug classes will be generated to aide clinical decision making.
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