PhD Opportunity – Understanding the regulation of inflammation by the ubiquitin system

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Project outline: Inflammatory responses rely on an intricate network of signalling events, which ensure that cells respond appropriately to insults, such as infections, toxic compounds, or cell damage. These responses need to be tightly controlled to prevent over- or under activation that could lead to disease. The ubiquitin pathway, which is a versatile post-translational protein modification system, is a major regulator of inflammatory signalling and this project is aimed at understanding the molecular details of how the ubiquitin system regulates inflammation.

We have identified a number of components of the ubiquitin system that are directly involved in the inflammatory response. With this project we will investigate where in the pathways this regulation occurs and how it is mediated on a molecular level, with the ultimate aim to identify new nodes of intervention to treat inflammatory disease.

The successful candidate will be trained in state-of-the-art technology, including CRISPR gene editing, protein mass spectrometry and primary human cell culture under the joint supervision of two experts in the field of inflammation and ubiquitin signalling, respectively.

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