PhD Scholarship: Characterisation and therapeutic targeting of novel functional interactions of the nuclear IGF-1R in rhabdomyosarcoma

Duration of Scholarship

The scholarships is full-time. It is expected that those awarded Scholarships will submit their thesis no later than three years from enrolment.

Starting dates: September 2023

Academic entry requirements

Applicants should have a minimum of an upper second class undergraduate degree, and ideally hold, or expect to achieve a merit or distinction in a master’s degree in a relevant subject from a UK university, or comparable qualifications from another recognised university. See: https://www.lsbu.ac.uk/international/your-country   for guidance on entry requirements from different countries.

PhD Scholarship Details:

School of Applied Sciences

Supervisor: Professor Eiman Aleem

Email:aleeme2@lsbu.ac.uk

Title: Characterisation and therapeutic targeting of novel functional interactions of the nuclear IGF-1R in rhabdomyosarcoma

Research Proposal:

Despite toxic therapy, the survival of children with high-risk rhabdomyosarcoma (ARMS) is 20-30%, which requires the discovery of novel less toxic treatment. IGF-1R is expressed in the nucleus (nIGF-1R) of ARMS and may contribute to the pathogenesis of the disease. Our aim is to identify novel druggable pathways regulated by nIGF-1R. Methods used include mass spectrometry and validation in patients’ samples by immunohistochemistry, ChiP seq to identify genes regulated by nIGF-1R. Targeting/disrupting novel critical molecular interactions will be conducted in silico.  Our data will provide the rationale for the development of selective targeted treatment for patients with high-risk ARMS.

Application Ref: IGF-1R-APS

How to apply for a LSBU PhD Scholarship

• Applications must be made online.

International students not holding a UK passport must also satisfy the UK Government regulations for entry to study in the UK.

Please use this link Signin – London South Bank Unversity (lsbu.ac.uk)

• Follow the application process search for the School of Applied Sciences, scroll down to see you see PhD Human Sciences
• In the funding section put LSBU scholarship
• Where it asks for supervisor add Professor Ge and add Reference IGF-1R-APS
• Add the above project title and project on a separate A4 document.
• You will also need to add two references, one of which must be an academic reference.
• You will also need to upload degree certificates and identity documents

Closing date for applications is: 30 June 2023

• Once your application is received it will be assessed by the lead supervisor and the supervisory team and a shortlist of candidates will be agreed.
• Shortlisted candidates will be invited for an online interview. The interview will assess the following:
• Reasons and motivations for undertaking a research degree and passion for the research topic
• Why you want to do a PhD at LSBU
• Ability for completing a PhD within the agreed time.
• Personal attributes such as creativity, confidence, tenacity, motivation, time management.
• Knowledge and understanding of research methods pertinent to the project. Be prepared to contribute your views on proposed methods of the selected project.
• Training and development need to undertake and compete a PhD successfully
• Additional needs necessary to complete the PhD successfully
• Your future career plans
• Other supporting information: recent publications if any or other research training and experience

We will inform you of the outcome of your application within two weeks of your interview.