University of Cambridge
Job title:
PhD Studentship: Discovering the determinants of host tropism of an emerging livestock pathogen
Company
University of Cambridge
Job description
This is a 3.5 year fully funded studentship including a UKRI-aligned stipend (£19,237 for 2024/25), a cost of living allowance of £2,200 per annum, and Home rated university tuition fees. International applicants may apply, however will attract tuition fees at the overseas rate and must show evidence of their ability to cover the difference between Home fees and Overseas fees for the duration of study.Students without English as a first language must provide evidence that they meet the English language requirement, e.g. with an average IELTS score of 7.0, as detailed: .The student will be registered with the University of Cambridge and will work at both The Pirbright Institute and in Cambridge. Highly subsidised Pirbright Institute student housing will be offered. A full range of research and transferrable skills training will be made available to the student as appropriate.Principal Supervisors: Dr Jonas Albarnaz (The Pirbright Institute), Prof Stephen Graham (University of Cambridge)Co-Supervisor: Dr Dalan Bailey (The Pirbright Institute)Research Group:PROJECT DETAILS:An evolutionary arms race for supremacy exists between viruses and their hosts’ immune systems. Viruses rely on cellular resources and machinery for their replication, and cells defend themselves from viruses by recognising and blocking infections. Therefore, viruses continually evolve new strategies (i) to subvert cellular biosynthetic machinery to support viral replication whilst (ii) escaping the host cell’s antiviral defences, and in turn hosts counter-evolve to overcome viral antagonism of their antiviral defences. Mammals are equipped with a complex immune system that plays an essential role fighting off viral infections through the actions of professional immune cells that recognise and mount an antiviral immune response, processes that have been investigated in detail. However, there exists another layer of immunity that functions at an intracellular level, where newly infected cells try to recognise and abort infection before the virus can take over the cellular biosynthetic machinery. We investigate these early virus-host interactions at the cellular level.Full Project Details:ELIGIBILITY AND FUNDING:This studentship is open to science graduates with, or who anticipate obtaining, at least a 2:1 or equivalent in a relevant biological subject in an undergraduate degree, or with a Masters degree – subject to university regulations. Other first degrees, e.g. veterinary science, will be considered. You should be looking for a challenging, interdisciplinary research training environment and have an active interest in the control of infectious diseases.Please quote reference PK44721 on your application and in any correspondence about this vacancy.The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Expected salary
Location
Cambridge
Job date
Fri, 17 Jan 2025 08:37:10 GMT
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