PhD Studentship: Discovery of enzymes for plastic degradation (SCI260)

University of Nottingham

Job title:

PhD Studentship: Discovery of enzymes for plastic degradation (SCI260)


College of Nottingham

Job description

Location: UK Different
Closing Date: Wednesday 22 Could 2024
Reference: SCI260Dr Dr and Dr Sam BryanUtility deadline: open till crammed, functions reviewed on a weekly foundationBeginning date: Oct 2024Funded PhD challenge (UK college students solely)Undertaking descriptionPlastic is a helpful materials for a variety of commercial functions. Polyethylene (PE) is likely one of the most used plastics, is available, gentle weight and sturdy. Nonetheless, PE takes 1000’s of years to degrade within the surroundings, resulting in a excessive environmental impression. It’s subsequently very important that plastic is collected and repurposed again in a round financial system. Equally, present recycling strategies (chemical or mechanical) progressively deteriorate the properties of the fabric, with the plastic ultimately reaching a stage the place it may now not be recycled utilizing present strategies and should be disposed of.We remoted an organism from the surroundings able to degrading PE in fermentation at a scale that has not beforehand been reported.The goal of this PhD challenge is to deal with the plastic degradation problem by investigating the processes and enzymes utilised by the remoted organism within the PE-degradation course of. Increase from our earlier research, the profitable candidate will determine, categorical and take a look at the exercise of a sequence of enzyme candidates. Appropriate strategies for testing the enzymatic exercise shall be developed over the course of the PhD and the enzymes shall be characterised through quite a lot of analytical strategies (e.g. biochemical assays, mass-spectrometry, crystallography, and many others.) with the objective of gaining insights into enzymatic plastic degradation.Shared between the Faculty of Chemistry and College of Engineering on the College of Nottingham, this challenge will present in depth coaching in protein expression and purification, enzyme assays and characterisation, and spectroscopy.Functions are invited from college students with a background in Chemistry, Biochemistry, Pure Sciences or a associated self-discipline, who’ve or anticipate to graduate with a first-class or robust 2:1 honours diploma, or a distinction or excessive benefit at MSc stage. The beginning date for the challenge shall be October 2024. Potential candidates are inspired to contact Dr Luisa Ciano ( ) and/or Dr Anca Pordea ( ) for extra particulars or enquiries in regards to the challenge.The place will stay open till crammed, functions shall be reviewed on a weekly foundation, therefore candidates are inspired to use as quickly as potential. Formal functions ought to embrace CV, cowl letter and tutorial transcripts, and needs to be made on-line by way of the College of Nottingham’s on-line utility system, indicating “Chemistry” for the Faculty and “Dr Luisa Ciano” because the supervisor:Funding notesFunding shall be confirmed as soon as the applicant is chosen. Absolutely funded studentship to start in October 2024. UK college students solely – tuition charges paid and full stipend, tax-free, for 42 months on the RCUK fee (presently £18,622 every year). Worldwide college students shall be thought-about provided that they maintain a scholarship to cowl the worldwide charges.Entry necessitiesCandidates ought to have, or anticipated to realize, at the least a 2:1 Honours diploma in Chemistry or a associated topic. A MChem/MSc-4-year built-in Grasp’s, a BSc + MSc or a BSc with substantial analysis expertise shall be extremely advantageous. Expertise in a number of of the next may even be helpful (however not important): biochemistry, organic chemistry, biocatalysis, spectroscopy.If English isn’t the candidate’s first language, they have to present proof earlier than the start of the studentship that they meet the College minimal English Language necessities (IELTS 6.0 with at the least 5.5 in every aspect).

Anticipated wage

£18622 per 12 months


United Kingdom

Job date

Sat, 24 Feb 2024 06:21:02 GMT

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