PhD Studentship: Gut Microbiome in Ageing – Is it the Answer to Leukaemia Progression

Main supervisor – Dr Stuart Rushworth

Acute myeloid Leukaemia (AML) accounts for 85,000 deaths and it’s estimated this can double by 2040. Presently AML stays incurable with a 5 yr survival of lower than 30%. AML is primarily a illness of the aged, with three quarters of sufferers identified after the age of 60 and presently the bulk (75%) of those sufferers die inside a yr of prognosis. On this venture with entry to human samples from AML sufferers the purpose of this examine is to find out the function of ageing induced adjustments in intestine microbiota on driving/influencing the development of AML.

The purpose of this venture is to outline the metabolic mechanisms underpinning AML development. Particularly, we’ll decide the function of adjustments in intestine microbiota induced by ageing in these processes. To do that, the PhD scholar will study in vivo methods together with animal dealing with, in addition to isolation of samples from people. The coed will obtain coaching in mobile biology methodologies together with, DNA isolation, library preparation and sequencing in addition to bioinformatic abilities to analyse the acquired sequencing knowledge.

The venture shall be carried out beneath the supervision of Dr Rushworth (Norwich Medical College). I’ve efficiently supervised 9 PhD college students who instantly left for post-doctoral positions. Our lab is a supportive and collaborative surroundings, holds weekly lab conferences, biweekly journal membership and encourages presentation at native, nationwide and worldwide conferences. Coaching offered will result in the event of superior analysis abilities in addition to different generic transferable abilities.

The Microbes, Microbiomes and Bioinformatics (MMB) Doctoral Coaching Partnership (DTP) is open to UK and Worldwide candidates with related undergraduate levels for entry in October 2024 and affords the chance to undertake a fully-funded 4-year PhD analysis venture supported by the UKRI Medical Analysis Council in microbiology and microbial bioinformatics.

Our distinctive and complete coaching programme empowers college students to really feel snug working refined pc analyses alongside laboratory work and emphasises problem-based studying in microbial bioinformatics, skilled improvement and analysis abilities. All MMB DTP college students undertake a Skilled Placement.

Interviews for shortlisted candidates will happen on Wednesday 15 Could 2024.

The MRC DTP is dedicated to equality, variety and inclusion. College students are chosen with out regard to age, incapacity, gender identification, marriage or civil partnership, being pregnant or maternity, ethnicity, faith or perception, intercourse or sexual orientation or social background. We worth curiosity, independence of thought, plus an inherent ability for analysis that mixes laboratory work and bioinformatics.

For data on eligibility and the best way to apply: www.uea.ac.uk/phd/mmbdtp

Extra Funding Data

This venture is awarded with a 4-year fully-funded studentship together with direct fee of tuition charges to the College, stipend for residing bills (2023/4 price: £18,622) and a Analysis Coaching Help Grant for annually of the studentship.