PhD Studentship in Physiology and Pharmacology: Investigating the Therapeutic Potential of Cannabidiol (CBD) in Cardiac Fibrosis

Supervisors:  Dr. Graeme Cottrell and Professor Darius Widera

Mission Overview:

Cardiac fibrosis is a situation that’s characterised by the irregular accumulation of fibrous tissue inside the coronary heart muscle and poses a major menace to cardiovascular well being. This fibrous tissue replaces wholesome cardiac muscle cells, disrupting the pure construction and performance of the guts. Linked with hypertension, coronary heart failure, and myocardial infarction, cardiac fibrosis progresses over time, leading to coronary heart muscle stiffness, compromised pumping capability, and heightened arrhythmia dangers, finally culminating in coronary heart failure and related issues.

Thrilling breakthroughs in analysis have make clear the potential of cannabidiol (CBD) to mitigate fibrosis and irritation, providing hope for efficient remedies. But, the exact mechanisms underlying the therapeutic results of CBD stay elusive.

This ground-breaking mission seeks to unravel the therapeutic potential of CBD in combating pivotal points of cardiac fibrosis, together with irritation ranges, cardiomyocyte differentiation, and extracellular matrix remodelling. Below the knowledgeable steering of Graeme Cottrell and Darius Widera, profitable candidates will obtain complete coaching in cutting-edge methods spanning cell biology, biochemistry, microscopy, molecular biology, experimental design, and knowledge evaluation.

Co-funded by MRX Medical, a number one participant in cannabinoid medicines, this collaboration provides a novel alternative to delve into drug discovery and translational science whereas gaining invaluable insights from an business perspective. Be a part of us in pioneering developments in cardiovascular analysis and shaping the way forward for cardiac care.

Embark on a transformative journey, the place scientific curiosity meets real-world influence. Apply now and be a part of a collaborative effort to revolutionize cardiac fibrosis therapy.

Eligibility: 

• Candidates ought to maintain or anticipate to achieve a minimal of a 2:1 bachelor’s diploma or equal in a Organic Science.
• As a consequence of restrictions on the funding this studentship is open to UK candidates.

Funding Particulars:   

• Begins: September 2024
• 4-year award
• Funding covers full tuition charges plus UKRI stipend (£19,237 pa for 2024/25).

The way to apply:  

To use click on ‘Apply’ and create your account, and use the hyperlink despatched by e-mail to begin the applying course of. In the course of the software course of please choose the PhD in Physiology and Pharmacology

*Necessary notes*

Please quote the reference ‘DRC24-021’ within the ‘Scholarships utilized for’ field which seems inside the Funding Part of your on-line software.

If the applying system prompts you to submit a analysis proposal, please paste within the mission title and transfer on to the subsequent step within the software.

Additional Enquiries:  

Please notice that, the place a candidate is profitable in being awarded funding, this can be confirmed through a proper studentship award letter; this can be offered individually from any Provide of Admission and can be topic to straightforward checks for eligibility and different standards. 

For additional particulars please contact Dr. Graeme Cottrell ([email protected] ) and/or Prof. Darius Widera ([email protected] ).