PhD Studentship: Lineage Tracing of Blood Stem Cell Development

Faculty of Well being, Drugs and Life Sciences

Funding for the Government Dean’s PhD Studentship: Lineage tracing of blood stem cell improvement in embryo-like gastruloids

The staff of Cristina Pina (https://www.brunel.ac.uk/folks/cristina-pina ), Alessandro Esposito (https://www.brunel.ac.uk/folks/alessandro-esposito ) and Victor Hernandez (https://www.brunel.ac.uk/folks/victor-hernandez ) at Brunel College London, is providing a fully-funded PhD studentship to develop a reside imaging and lineage tracing system to observe blood formation and emergence of blood (haematopoietic) stem cells in a 3D gastruloid mannequin of embryogenesis. Institution of the lineage tracing system will assist implementation of the 3D gastruloid mannequin as a substitute for animal research, and its eventual use as a supply of blood cells for transfusion and transplantation.

Based mostly in and funded by the Faculty of Well being, Drugs and Life Sciences, this studentship affords a full-time annual London charge stipend estimated at £21,237plus (together with London weighting) and Dwelling/EU tuition charges, for a most of 36 months.

The Division of Life Sciences holds a Silver Athena SWAN Award and is dedicated to equality of alternative and advancing ladies’s careers.

The beginning date shall be 1 October 2024.

Overview

The overarching purpose of this mission is the optimisation of tradition circumstances for the scalable technology of haematopoietic stem cells (HSCs) in vitro from pluripotent sources. This paves the trail for on-demand laboratory manufacturing of HSC and blood cells, overcoming the restrictions of voluntary blood donations and tissue compatibility, and addressing an unmet medical want.

The mission brings collectively established PIs’ experience in regulation of haematopoiesis and HSCs and in biophotonics and reside imaging options. It’s actually interdisciplinary and can present the profitable Candidate with strong publicity to molecular biology, stem cell biology, organoid bioengineering, and superior reside microscopy, increasing their future employability and profession alternative.

For casual discussions, please contact Cristina Pina ([email protected] ) and/or Alessandro Esposito ([email protected] ).

Eligibility

Candidates ought to have an undergraduate diploma (first or higher second class) or equal qualification in a Organic or Bioengineering self-discipline. A Masters qualification in a related space is fascinating however not important. Earlier analysis expertise in cell and/or molecular biology are fascinating standards. Candidates who haven’t been awarded a level by a College within the UK shall be anticipated to show English language expertise to IELTS 7.0 (minimal 6.5 in any part).

Tips on how to Apply

In the event you want to apply, please e-mail the next to [email protected] by 10 June 2024.

• An up-to-date CV.
• A single-page A4 single-spaced private assertion describing why you’re a appropriate candidate (i.e. outlining your {qualifications} and expertise).
• One instance of your tutorial writing (e.g. an essay, a piece from a dissertation).
• A abstract of your instructing expertise or your willingness to assist instructing actions.
• Names and make contact with particulars for 2 tutorial referees.
• A replica of your highest diploma certificates and transcript.
• A replica of your English language qualification, the place relevant.

Brief-listed candidates shall be required to attend an interview week commencing 1 July 2024.

For additional details about find out how to apply, please contact the Faculty of Well being, Drugs and Life Sciences Postgraduate Programmes Workplace on [email protected] .