University of Sussex
PhD Studentship
Genome Stability
College of Sussex
Funding for: UK College students
Funding quantity: Dwelling (UK) tuition charges and stipend at customary UKRI charges.
A PhD studentship (3.5 years) is accessible from September 2024 underneath the supervision of Prof. Timothy Humphrey, Genome Harm & Stability Centre (GDSC), College of Life Sciences.
Deadline: twenty eighth February 2024
Challenge Title
Focusing on chromatin defects in most cancers
The challenge
All DNA transactions, together with DNA replication, DNA restore and transcription happen inside the context of chromatin. Accordingly, mutations affecting chromatin may end up in wide-ranging pleiotropic results, which might result in genetic illness, together with most cancers. In keeping with this, acquire or lack of operate mutations in histone variants, chromatin remodellers, and histone modifiers are ceaselessly noticed in cancers, thereby representing actionable vulnerabilities.
The purpose of this challenge is to focus on explicit chromatin defects to deal with most cancers. This will likely be achieved via initially confirming the suitability of explicit mutations as most cancers targets. Secondly, artificial deadly interactions with these mutations will likely be recognized, utilizing mannequin techniques, together with yeast and human cell strains. Lastly, we are going to exploit these artificial deadly interactions obtained to focus on cancers carrying explicit chromatin mutations of curiosity. Utilizing this strategy, we now have contributed to medical trials concentrating on SETD2-deficient cancers (Pfister et al., Most cancers Cell 2015); P53-KRAS colorectal cancers (Seligmann et al., J Clin Oncol 2021) with others in progress. Methods will embrace yeast and mammalian genetics, CRISPR, molecular biology, biochemistry and immunohistochemistry.
The group
You’ll work inside the Chromatin Integrity Group led by Prof. Timothy Humphrey, within the Genome Harm and Stability Centre, which is a Centre of Excellence on the College of Sussex, Brighton. We profit from robust interactions with discovery and medical researchers, the Sussex Drug Discovery Centre, Life Sciences and pharmaceutical corporations.
Casual enquiries concerning the challenge may be made to Prof Timothy Humphrey at [email protected]
How you can apply:
Please submit a proper software utilizing the net admissions portal attaching a CV, diploma transcripts and certificates, private assertion, and two educational referees. A analysis proposal isn’t required.
On the applying system choose Programme of Examine – PhD Genome Stability. Please state the challenge title underneath funding obtained and the supervisor’s identify the place required.
Candidates ought to have or anticipate to acquire a minimal 2:1 undergraduate diploma. An MSc diploma will likely be advantageous. Your qualification needs to be in Genome Stability or a associated topic space. You may additionally be thought of for the place you probably have different skilled {qualifications} or expertise of equal standing.
Candidates for whom English isn’t their first language would require an IELTS rating of 6.5 general, with not lower than 6.0 in any part – English language necessities
Functions are notably welcomed from candidates with protected traits – e.g., from Black and different ethnic minorities – who’re under-represented in postgraduate analysis at our establishment.
For enquiries concerning the software course of, please e-mail Emma Chorley: [email protected]
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