PhD Studentship: The Oxylipidome in the Pathophysiological Links between Periodontal Disease and Inflammatory Bowel Diseases

Closing Date: fifteenth April 2024 [23.59 GMT]

Supervisor: Irundika Dias

Potential Begin Date: 1 July 2024

Key phrases: Neutrophils, biomarkers, lipids, irritation

Purposes are invited for a Postgraduate studentship, supported by the School of Well being and Life Sciences and the College of Birmingham to be undertaken at Aston College.

Monetary Assist

This studentship features a charge bursary to cowl the house charges charge, plus a upkeep allowance of £18,622 in 2023/4.

Abroad Candidates

Abroad candidates could apply for this studentship however might want to pay the distinction between the ‘Residence’ and the ‘Abroad’ tuition charges. Presently the distinction between ‘Residence’ and the ‘Abroad’ tuition charges is £13,688 in 2023/4.  As a part of the applying, you’ll be required to verify that you’ll present this extra funding. Please point out this on the applying type within the funding part.

Particulars of the Undertaking

Power inflammatory periodontitis is understood to be an impartial threat issue for systemic non-communicable ailments akin to diabetes, power kidney illness, heart problems, and rheumatoid arthritis, IBD, highlighting the profound impression that oral well being can have on systemic well being [1]. Latest work from Professor Iain Chapple (affiliate supervisor for this studentship) and Professor Tariq Iqbal at Birmingham’s NIHR Biomedical Analysis Centre (BRC) has revealed compelling associations with periodontal illness and inflammatory bowel illness (IBD) [2]. Each PD and IBD share a standard function – underlying mucosal irritation within the affected tissues. Present proof strongly means that peripheral blood neutrophils in sufferers with power inflammatory ailments are hyper-responsive in respect of reactive oxygen species (ROS) technology. Neutrophil hyperactivity and hyperreactivity results in tissue harm immediately or via oxidation of lipids and proteins inside the neighborhood [3]. This venture proposes to analyze the involvement of oxylipids within the intricate connection between PD and IBD. Unravelling oxylipid connections for the bidirectional affect of oral and intestine microbiomes and irritation of the oral cavity and the intestine holds promise for early analysis via the evaluation of molecular signatures. This strategy not solely improve the differentiation between numerous kinds of IBD but additionally lay the muse for the event of revolutionary focused therapies.

References:

https://pubmed.ncbi.nlm.nih.gov/26881700/

https://www.birmingham.ac.uk/information/2022/opinion-understanding-the-link-between-oral-and-gut-health

https://pubmed.ncbi.nlm.nih.gov/31644951/

Individual Specification

The profitable applicant ought to have been awarded, or anticipate to realize, a Masters diploma in a related topic with a 60% or larger weighted common, and/or a First or Higher Second Class Honours diploma (or an equal qualification from an abroad establishment) in a related topic. Most popular talent necessities embody information/expertise of cell tradition, protein or lipid biomarker evaluation.

Contact info

For casual enquiries please e-mail: Dr Irundika Dias [email protected]

Submitting an utility

For full particulars on how one can apply, please click on the ‘Apply’ button.