PhD Studentship: The Oxylipidome in the Pathophysiological Links between Periodontal Disease and Inflammatory Bowel Diseases

Closing Date: fifteenth April 2024 [23.59 GMT]

Supervisor: Irundika Dias

Potential Begin Date: 1 July 2024

Key phrases: Neutrophils, biomarkers, lipids, irritation

Functions are invited for a Postgraduate studentship, supported by the School of Well being and Life Sciences and the College of Birmingham to be undertaken at Aston College.

Monetary Help

This studentship features a payment bursary to cowl the house charges charge, plus a upkeep allowance of £18,622 in 2023/4.

Abroad Candidates

Abroad candidates could apply for this studentship however might want to pay the distinction between the ‘House’ and the ‘Abroad’ tuition charges. Presently the distinction between ‘House’ and the ‘Abroad’ tuition charges is £13,688 in 2023/4.  As a part of the applying, you’ll be required to substantiate that you’ll present this extra funding. Please point out this on the applying type within the funding part.

Particulars of the Mission

Power inflammatory periodontitis is understood to be an unbiased threat issue for systemic non-communicable illnesses equivalent to diabetes, power kidney illness, heart problems, and rheumatoid arthritis, IBD, highlighting the profound influence that oral well being can have on systemic well being [1]. Latest work from Professor Iain Chapple (affiliate supervisor for this studentship) and Professor Tariq Iqbal at Birmingham’s NIHR Biomedical Analysis Centre (BRC) has revealed compelling associations with periodontal illness and inflammatory bowel illness (IBD) [2]. Each PD and IBD share a standard function – underlying mucosal irritation within the affected tissues. Present proof strongly means that peripheral blood neutrophils in sufferers with power inflammatory illnesses are hyper-responsive in respect of reactive oxygen species (ROS) era. Neutrophil hyperactivity and hyperreactivity results in tissue harm straight or by oxidation of lipids and proteins throughout the neighborhood [3]. This challenge proposes to research the involvement of oxylipids within the intricate connection between PD and IBD. Unravelling oxylipid connections for the bidirectional affect of oral and intestine microbiomes and irritation of the oral cavity and the intestine holds promise for early prognosis by the evaluation of molecular signatures. This strategy not solely improve the differentiation between numerous varieties of IBD but additionally lay the inspiration for the event of modern focused therapies.

References:

https://pubmed.ncbi.nlm.nih.gov/26881700/

https://www.birmingham.ac.uk/information/2022/opinion-understanding-the-link-between-oral-and-gut-health

https://pubmed.ncbi.nlm.nih.gov/31644951/

Individual Specification

The profitable applicant ought to have been awarded, or anticipate to attain, a Masters diploma in a related topic with a 60% or larger weighted common, and/or a First or Higher Second Class Honours diploma (or an equal qualification from an abroad establishment) in a related topic. Most well-liked ability necessities embody data/expertise of cell tradition, protein or lipid biomarker evaluation.

Contact info

For casual enquiries please electronic mail: Dr Irundika Dias [email protected]

Submitting an software

For full particulars on learn how to apply, please click on the ‘Apply’ button.