PhD Studentship: Understanding and enhancing the physiological resilience of older adults to improve health-span: a focus on skeletal muscle. (MED2003)

Job title:

PhD Studentship: Understanding and enhancing the physiological resilience of older adults to enhance health-span: a give attention to skeletal muscle. (MED2003)

Firm

College of Nottingham

Job description

Location: UK Different
Closing Date: Saturday 20 April 2024
Reference: MED2003Principal supervisors:PhD 1 – Prof Philip Atherton (Faculty of Medication) –PhD 2 – Prof Paul Greenhaff (Faculty of Life Sciences) –PhD 3 – Prof Bethan Phillips (Faculty of Medication) –Funded by the Dunhill Medical Belief ( ) as one in all their A number of PhD Studentship Awards, we’ve three fully-funded (stipend at UKRI charges, PhD charges (for UK nationals solely) and analysis prices) three-year full-time PhD’s out there, every to start out on the first October 2024.Every of those tasks relies across the frequent theme of enhancing the physiological resilience of older adults, with a particular give attention to skeletal muscle.Programme description: Lack of resilience describes enhanced vulnerability to, and impaired restoration from stress occasions when in comparison with a sturdy [youthful/healthy] state; and is usually encountered with advancing age. With ageing populations world wide, and the related rise in years spent in ill-health, there’s an pressing want to grasp the mechanisms underpinning this lack of physiological resilience, and potential methods to mitigate these declines. Though a current nationwide GIRFT (Getting It Proper First Time) report means that enhancing frailty administration might save the NHS
£600-million/12 months, furthering understanding of the organic mechanisms driving lowered resilience to tell on precision mitigation methods (i.e., for the fitting individuals on the proper time) might in actual fact have a a lot greater affect. This affect would favour not solely on healthcare methods but in addition older people, their assist networks and society as a complete. Proof means that skeletal muscle deterioration, together with metabolic and purposeful decline, is a core driver of lowered resilience in older adults each with and with out illness. Certainly, skeletal muscle weak spot is on the fore of each frailty (the scientific time period encompassing lack of resilience) and sarcopenia (age-associated losses of muscle mass and performance) definitions. A devastating consequence of lowered resilience is that the time individuals spend in good well being (their health-span) is now a lot shorter than general lifespan; a difficulty that we purpose to assist tackle by means of this assortment of PhD’s.PhD descriptions:PhD 1 – Drug repurposing is an rising avenue of analysis within the discipline of Geroscience; a discipline whose said purpose is to “speed up reseach into the essential mechanisms driving ageing which might result in improved scientific interventions”. Based mostly on the College of Nottingham Medical Faculty at Derby (UNMSD; Royal Derby Hospital Centre), this PhD is focussed on exploring the affect of an already-licensed mechanistic goal of rapamycin (mTOR) inhibitor (which has been proven to attenuate sarcopenia in animal fashions of ageing) on muscle progress and performance in each community-dwelling older adults and orthogeriatric sufferers. Outcomes from this PhD will inform on the potential of mTOR inhibition to boost the resilience of older adults, not solely in relation to skeletal muscle but in addition different organ methods for which beneficial pre-clinical knowledge is rising (i.e., the immune system). As is the case for all of those PhD’s, the profitable candidate will be taught a wealth of expertise referring to human physiology research/scientific trials and state-of-the-art wet-lab strategies.PhD 2 – Sturdy proof relating to the organic mechanisms liable for the well being advantages of bodily exercise, and the detrimental impacts of inactivity is missing. This PhD will purpose to deal with the long-standing debate surrounding the function of recurring bodily exercise ranges in driving ageing processes in a number of organs, with a selected give attention to skeletal muscle. The profitable candidate shall be built-in right into a multidisciplinary crew dovetailing magnetic resonance imaging, biotechnology and human physiology experience, which can allow a complete array of endpoints to be quantified over the course of a 6 month managed bodily exercise intervention. A selected focus of this PhD mission shall be understanding the contribution of metabolic and physiological modifications in skeletal muscle with altered bodily exercise ranges. This PhD will present distinctive coaching in metabolic physiology and shall be primarily based throughout 3 websites, the Sir Peter Mansfield Imaging Centre and Queens Medical Centre (QMC) on the College of Nottingham College Park campus and the UNMSD.PhD 3 – Along with rehabilitation, which has lengthy been employed as methodology to boost restoration from scientific stress occasions, there’s burgeoning scientific and analysis curiosity in prehabilitation, an method employed to organize people for these occasions. Based mostly on the College of Nottingham Medical Faculty at Derby (UNMSD; Royal Derby Hospital Centre), this PhD will take into account the significance of, and strategies for the preservation of muscle mass and performance in older affected person cohorts. With elective surgical procedure a transparent and customary instance of a stress occasion encountered by older adults, and recognising that physiological resilience isn’t just preparedness for stress occasions but in addition the flexibility to get better from them, this PhD will give attention to practicable pre- and rehabilitation methods in older surgical sufferers. Exploring the interplay between novel contractile methods and dietary consumption, outcomes from this PhD will present an evidence-base for methods to be applied as an adjuvant to straightforward care within the peri-operative interval of older surgical sufferers.All of those PhD’s will profit from the experience and expertise of multi-disciplinary supervisory groups comprised of discovery scientists and scientific teachers.Additional data:Candidates ought to have both:

• a minimal of a 2.1 in a related undergraduate diploma (e.g., Train Science, Physiology, Biology, Biomedical Sciences (non-exhaustive record)), OR
• a minimal of a 2.2 undergraduate diploma and a related Grasp’s diploma.

The best candidate may even have expertise of human physiology and or laboratory analysis and an understanding of ageing physiology.Casual enquiries could also be addressed to the programme lead, Prof Bethan Phillips ( ) or to the principal supervisor for every PhD.To use, candidates ought to ship their CV and a brief cowl letter (
1000 phrases) outlining why they’re making use of to be a part of this PhD programme and what they consider they will provide to: . The e-mail topic line needs to be: “DMT PHD APPLICATION”. Candidates could apply for greater than one of many PhDs listed, however ought to make this recognized of their cowl letter. Candidates also needs to present the contact particulars for two referees, one in all whom needs to be their most up-to-date educational supervisor (or line supervisor in related employment, if relevant). Please be aware, presents of research shall be topic to 2 passable references being acquired.Closing Date for Functions: Monday April twentieth 2024, 10:00amProvisional Interview Dates: twenty eighth and twenty ninth Might 2024In case you will be unable to attend an interview on the College of Nottingham Medical Faculty at Derby on these dates please make this recognized once you electronic mail your utility to Prof Bethan Phillips so different preparations might be thought-about if attainable.PhD Begin Date: 1st October 2024, or as quickly as attainable thereafter.

Anticipated wage

Location

Derby

Job date

Sat, 23 Mar 2024 03:55:38 GMT

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