Post-Doctoral Research Associate

Job title:

Post-Doctoral Research Associate

Company

University of Edinburgh

Job description

Job Description:Post-Doctoral Research AssociateThe Opportunity:An exciting postdoctoral position is available to research the role of epigenetic dysregulation in carcinogenesis.We are looking for a self-motivated, enthusiastic research fellow to join the laboratory of Dr Duncan Sproul at the University of Edinburgh’s Institute of Genetics and Cancer to understand the role of heterochromatin hypomethylation in carcinogenesis. This project is a close collaboration with Kevin Myant’s laboratory based within the same institute.We have recently shown that the DNA methyltransferase DNMT3B is required to maintain heterochromatic DNA methylation in colorectal cancer cells (Taglini et al. 2024, EMBO Reports 25:1130, DOI: 10.1038/s44319-024-00061-5). Our new project will use this insight as a tool to understand the role of heterochromatin hypomethylation in colorectal carcinogenesis where DNMT3B is a tumour promoting gene (Lin et al 2006, Molecular and Cellular Biology 26:2976, DOI: 10.1128/MCB.26.8.2976-2983.2006).The successful candidate will work in collaboration with both the Sproul and Myant laboratories as part of a successful multidisciplinary research team. This project will have a particular emphasis on the use of degron approaches in colorectal organoids and the analysis of epigenomic data from Nanopore sequencing. The project team also includes additional collaborators in Edinburgh, Exeter and Oxford.Candidates who have been awarded, or are soon to be awarded, a PhD in a relevant discipline and have experience with a broad range of molecular biology, biochemistry and computational data approaches are invited to apply. Applicants must possess the ability to think independently while working within an interdisciplinary research team to drive research projects towards publication. Candidates with a strong track record in epigenomics and/or colorectal cancer biology are particularly welcome.The post is full-time (35 hours per week) and fixed term – funding is available from 1st May 2025 for 3 years pending review after 6 months.The salary for this post is UE07 £40,247 to £47,874 per annumFurther details of work from the Sproul and Myant groups are available at:Informal enquiries can be made toClick to view a copy of the full job description.The Institute of Genetics and CancerThe Institute of Genetics and Cancer is an international research institute that is part of the University of Edinburgh and is located on the Western General Hospital campus. It hosts 70 research groups and over 500 scientists, support staff, fellows, PhD students and visiting scientists. The institute has a strong culture of collaboration, interaction and mentoring diverse careers.As a valued member of our team you can expect:

• A competitive salary
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community
• Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefitsChampioning equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University of Edinburgh you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab)On this occasion the University will not consider applicants requiring sponsorship for this role. International workers will therefore only be able to take up this role if they can demonstrate an alternative right to work in the UK.Application detailsThe closing date for applications is 14 February 2025.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.Interviews will be held during the week beginning 10th March 2025. Following the interview, the successful applicant will have the opportunity to visit the Institute of Genetics and Cancer.About the Team:A deep understanding of human genome function – particularly for the non-coding genome – is an outstanding grand challenge. Our mission is to discover how our genome controls the function of molecules, cells and tissues, in health and disease, connecting human genetic variation to phenotype.Multidisciplinary HGU research programs embrace genetic, computational, biochemical, cellular, model organism and clinical approaches, to gain meaningful insights across scales and dynamic processes, with cross-cutting themes in 4D Cellular Medicine and Genome Interpretation.To find out more visitThe MRC Human Genetics Unit is part of the Institute of Genetics and Cancer (IGC). This partnership with CRUK Edinburgh Centre and Centre for Genomic and Experimental Medicine Centre aims to understand development and disease by using the latest developments in genetic, genomic, cellular and clinical science. The partnership provides access to state of the art scientific facilities, scientific infrastructure and business support, including on site Advanced Imaging Resource, Animal Model support, Bioinformatics Analysis Core, DNA sequencing, Flow Cytometry, Mass Spectrometry, HTPU microarray. The IGC also offers a highly collegial environment with excellent local career development support, active social, wellbeing and sustainability related groups making it a very desirable and supportive working environment.To find out more visit

Expected salary

£40247 – 47874 per year

Location

Edinburgh – Midlothian

Job date

Wed, 05 Feb 2025 07:09:39 GMT

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