University of Cambridge
Understanding Mechanisms in Familial Interstitial Lung Illness Utilizing Organoid Fashions
Dr Dickens and the Marciniak Group are searching for a postdoctoral researcher to drive innovation in a programme of analysis investigating triggers of alveolar epithelial dysfunction in familial types of interstitial lung illness. You’ll work with novel alveolar organoids, creating patient-specific fashions which you’ll interrogate utilizing progressive tradition strategies, genetic manipulation and
multi-omics evaluation together with proteomics and transcriptomics with a view to figuring out novel therapeutic targets.
It’s best to have a monitor report in wet-lab cell biology and possess a PhD in a related self-discipline. Prior expertise of working with organoids could be a bonus, however coaching shall be offered.
The profitable applicant will be part of Dr Dickens, a clinician scientist, and a various staff of fundamental and translational scientists and clinicians throughout the Marciniak Group. We’re dedicated to selling an thrilling, rewarding and wholesome working atmosphere and try to help the profession targets of our staff members.
The Cambridge Institute for Medical Analysis (CIMR) is situated on the Cambridge Biomedical Campus and it’s a collaborative institute on the interface between elementary analysis and the clinic, with a mission to find out the molecular mechanisms of illness with a purpose to advance human well being.
Current related papers
Lim Ok, Rutherford EN, Solar D, Van den Boomen DJH, Edgar JR, Bang J, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid mannequin reveals mechanisms of surfactant protein C maturation related to interstitial lung illness. BioRxiv (https://doi.org/10.1101/2023.08.30.555522 )
Dickens JA, Rutherford EN, Abreu S, Chambers JE, Ellis MO, van Schadewijk A, Hiemstra P, Marciniak SJ. Novel insights into surfactant protein C trafficking revealed via the research of a pathogenic mutant. Eur Respir J 2022;59:2100267
Please contact Dr Jenny Dickens at [email protected] for additional data.
Fastened-term: The submit will run for 3 years within the first occasion.
We welcome purposes from people who want to be thought-about for part-time working or different versatile working preparations.
Click on the ‘Apply’ button under to register an account with our recruitment system (in case you have not already) and apply on-line.
Please make sure that you add a overlaying letter and a CV within the Add part of the net software. The overlaying letter ought to define the way you match the standards for the submit and why you’re making use of for this function. When you add any extra paperwork which haven’t been requested, we won’t be able to contemplate these as a part of your software.
Please embrace particulars of your referees, together with e mail tackle and telephone quantity, one among which have to be your most up-to-date line supervisor.
The deadline for purposes is: seventeenth April 2024
The interview date for the function is: Starting of Might 2024
Please quote reference SC40999 in your software and in any correspondence about this emptiness.
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The College has a duty to make sure that all workers are eligible to dwell and work within the UK.
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