Post-Doctoral Research Associate-membrane proteins-rays, mass spec

Job title:

Post-Doctoral Research Associate-membrane proteins-rays, mass spec

Company

Diamond Light Source

Job description

Based onsite at Diamond in HarwellAbout UsDiamond Light Source is the UK’s national synchrotron science facility, and a leading scientific facility of its type in the world. By accelerating electrons to near light-speed, Diamond generates brilliant beams of light from infra-red to X-rays which are used for academic and industry research and development across a range of scientific disciplines. Diamond also houses the electron bioimaging centre, the UK’s national cryo-electron microscopy facility, which provides state-of-the art cryo-EM facilities free at the point of access to academic users. The Membrane protein laboratory at Diamond was established in 2007 to provide a state-of-the art facility to support the efficient determination of relevant membrane protein structures and has contributed to at least one membrane protein structure a year since 2010.About the RoleWe now have an opportunity for a motivated scientist to take on a post-doctoral research position between the (MPL) and the (SCM) based at Diamond.The successful candidate will focus on the development of methods to enable structural characterization of proteins in the solution-state. X-ray footprinting mass spectrometry and diffracted X-ray tracking (DXT) are two new techniques being developed at beamline B21, to provide complementary information to bioSAXS and cryo-structural biology investigations. To facilitate this, the successful candidate will work with state-of-the-art equipment that includes a Waters Xevo G3 Q-ToF and high-throughput protein production facilities while using a set of membrane protein associated with childhood dementia as test case for these new developments.The role will also involve developing new expression and sample delivery methods as well as different data collection strategies using both X-ray diffraction and absorption and mass spectrometry.In addition to these research activities the successful candidate will also have the opportunity to contribute to the MPL and SCM user programmes (approximately 10%). This involves facilitating data collection on the B21 and sample preparation for SAXS at the MPL. The position is funded for two years in the first instance with the possibility of a 1-year extension.About YouYou will have an appropriate Science Degree and PhD, along with proven experience and research interest in relevant areas.You should have experience of working with membrane proteins and be familiar with mass spectrometry. Experience of molecular biology, protein production or Linux based computing would be advantageous.You will display good interpersonal, communication and presentational skills in order to interact with facility staff and users at all level.BenefitsDiamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 26 days annual leave plus Christmas closure, public holidays, 2 annual volunteering days and flexible working hours. We also offer an excellent defined benefit pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable.To ApplyPlease use the online application process to apply and tell us why you believe you are suitable for this role.The closing date for applications is 30th June 2024, however, we encourage early applications as some candidates may be interviewed before this date.Business AreaScienceFull Time Salary£37,087 to £40,754 per annumPost TypeFull time / PermanentTerm2 yearsClosing Date30/06/2024

Expected salary

£37087 – 40754 per year

Location

England

Job date

Fri, 07 Jun 2024 02:34:51 GMT

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