Postdoctoral Fellow – Chudnovskiy Lab

Job title:

Postdoctoral Fellow – Chudnovskiy Lab

Firm

Francis Crick Institute

Job description

Postdoctoral Fellow – A. Chudnovskiy lab.Reporting to: Aleksey Chudnovskiy, Group ChiefContact time period: This can be a full time 4-year place on Crick phrases and situations of employment.The Analysis GroupThe laboratory of Tumour-Immune Communication has been established in early 2024. We research bidirectional interactions between most cancers cells and the host immune system utilizing artificial and molecular biology, genetics, and immunology. This analysis delineates how interplay dynamics between tumour cells and immune cells affect one another, contributing to our understanding of tumour development and antitumour immune response.The VentureThis undertaking is designed to grasp the interactions between tumour cells and immune cells utilising a wide range of tumour cell strains and genetic fashions, with a main however not unique give attention to lung most cancers and lung metastases. Our laboratory is provided to trace tumour-immune interactions on the single cell stage. The LIPSTIC system-Labeling Immune Partnerships by SorTagging Intercellular Contacts-is used to unravel the mobile communication inside the tumour microenvironment, concentrating on the interactions between tumour cells and immune cells, in addition to between completely different antigen-presenting cells and T cells. The postdoctoral researcher will make use of superior genetic and molecular biology strategies in addition to loads of scRNA-seq to research the ideas that govern the dynamics of tumour-immune interactions, aiming to use this understanding to the event of most cancers remedies. The work will contain the research of a variety of tumour fashions, with an emphasis on lung most cancers and different cancers that metastasise to the lung. The preliminary part of the undertaking will characterise the character of tumour-immune interactions throughout steady-state tumour progress and after therapeutic interventions. Within the later phases, the undertaking is more likely to evolve into an in depth mechanistic research of the interactions between particular immune cell populations and tumour cells. The last word purpose is to utilise the findings from these research to boost therapeutic approaches for most cancers.The postholder shall be answerable for:Performing preliminary characterization of tumor-immune interactions at a single cell stage utilizing LIPSTIC and different cell-cell interplay tracing strategies.Understanding molecular mechanisms that drive tumor-immune interactions.Manipulating tumor-immune interactions to boost antitumor immunity.Postdoctoral Fellows will lead their very own tasks, contribute to different tasks on a collaborative foundation (each within the lab and with exterior collaborators) and should information PhD college students of their analysis. The power to work in a group is crucial.Key expertise and competenciesThe publish holder ought to embody and display our core Crick values:Daring; Open; CollegialImportantPhD in immunology, most cancers biology, molecular or mobile biology or within the last phases of PhD submissionGood data and expertise in immunology and/or tumor biology and/or molecular or mobile biologyTechnical experience in primary immunological and/or molecular and/or mobile biology strategies.Observe file of writing papers as evidenced by publications or submitted manuscripts in referred journalsProof of information presentation at scientific conferencesFascinatingExpertise in analysis with mouse tumour fashions cell strains or genetic tumour fashionsGood understanding of innate and adaptive immunityExpertise in movement cytometry, single cell sequencing, Cas9 primarily based genetic screens, single cell RNA-seq knowledge evaluation utilizing R or PythonAbout UsOn the Crick, we conduct analysis on the forefront of biomedical analysis. We mix rigour with an open and collaborative tradition, and are outward-looking, reflecting our standing as a partnership of six organisations aiming to pool data, concepts and assets.We’ve a large analysis portfolio with no divisions or departments, bringing biomedical researchers along with clinicians, bodily scientists and utilized scientists from our pharmaceutical companions.We intention to draw essentially the most gifted researchers and help them to sort out modern analysis questions. Our science expertise platforms present our researchers with entry to state-of-the-art expertise and experience.We offer a wonderful studying setting with devoted training programmes in public engagement with science, training and private improvement, and a postdoc coaching programme that prepares scientists for management roles in science.In case you are interested by making use of for this position, please apply by way of our .All affords of employment are topic to profitable safety screening and steady eligibility to work in the UK.In the event you require a visa to work within the UK we’ll assist help your software must you achieve successEquality, Variety & InclusionWe welcome functions from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender id, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We notably welcome functions from people who find themselves Minority Ethnic as they’re at present underrepresented within the Crick at this stage.Variety is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We would like the Crick to be a spot the place everybody feels valued and the place range is well known and seen as a part of the inspiration for our Institute’s success.The Crick is dedicated to creating equality of alternative and selling range and inclusivity. All of us share within the accountability to actively promote dignity, respect, inclusivity and equal therapy and it’s our intention to make sure that these ideas are mirrored and applied in all methods, insurance policies and practices.Learn extra on our web site:Discover out what advantages the Crick has to supply:For extra info on our nice pay and advantages bundle please click on right here:

Anticipated wage

Location

London

Job date

Tue, 19 Mar 2024 23:07:12 GMT

To assist us observe our recruitment effort, please point out in your e-mail/cowl letter the place (globalvacancies.org) you noticed this job posting.