Postdoctoral Fellow – Chudnovskiy Lab

Job title:

Postdoctoral Fellow – Chudnovskiy Lab

Firm

Francis Crick Institute

Job description

Wage for this Function:

From £43,210, topic to abilities and expertise

Job Title:

Postdoctoral Fellow – Chudnovskiy Lab

Studies to: Aleksey Chudnovskiy

Closing Date: 12/Could/2024 23.59 GMT

Job Description:

Postdoctoral Fellow – A. Chudnovskiy lab.

Reporting to: Aleksey Chudnovskiy, Group Chief

Contact time period: This can be a full time 4-year place on Crick phrases and situations of employment.

The Analysis Group

The laboratory of Tumour-Immune Communication has been established in early 2024. We examine bidirectional interactions between most cancers cells and the host immune system utilizing artificial and molecular biology, genetics, and immunology. This analysis delineates how interplay dynamics between tumour cells and immune cells affect one another, contributing to our understanding of tumour development and antitumour immune response.

The Challenge

This undertaking is designed to grasp the interactions between tumour cells and immune cells utilising a wide range of tumour cell strains and genetic fashions, with a main however not unique deal with lung most cancers and lung metastases. Our laboratory is supplied to trace tumour-immune interactions on the single cell stage. The LIPSTIC system—Labeling Immune Partnerships by SorTagging Intercellular Contacts—is used to unravel the mobile communication throughout the tumour microenvironment, concentrating on the interactions between tumour cells and immune cells, in addition to between totally different antigen-presenting cells and T cells. The postdoctoral researcher will make use of superior genetic and molecular biology methods in addition to quite a lot of scRNA-seq to research the ideas that govern the dynamics of tumour-immune interactions, aiming to use this understanding to the event of most cancers therapies. The work will contain the examine of a variety of tumour fashions, with an emphasis on lung most cancers and different cancers that metastasise to the lung. The preliminary section of the undertaking will characterise the character of tumour-immune interactions throughout steady-state tumour development and after therapeutic interventions. Within the later levels, the undertaking is more likely to evolve into an in depth mechanistic examine of the interactions between particular immune cell populations and tumour cells. The final word purpose is to utilise the findings from these research to boost therapeutic approaches for most cancers.

The postholder might be accountable for:

Performing preliminary characterization of tumor-immune interactions at a single cell stage utilizing LIPSTIC and different cell-cell interplay tracing methods.

Understanding molecular mechanisms that drive tumor-immune interactions.

Manipulating tumor-immune interactions to boost antitumor immunity.

Postdoctoral Fellows will lead their very own initiatives, contribute to different initiatives on a collaborative foundation (each within the lab and with exterior collaborators) and should information PhD college students of their analysis. The flexibility to work in a crew is crucial.

Key expertise and competencies

The put up holder ought to embody and reveal our core Crick values:

Daring; Open; Collegial

Important

PhD in immunology, most cancers biology, molecular or mobile biology or within the remaining levels of PhD submission

Good data and expertise in immunology and/or tumor biology and/or molecular or mobile biology

Technical experience in primary immunological and/or molecular and/or mobile biology methods.

Monitor document of writing papers as evidenced by publications or submitted manuscripts in referred journals

Proof of knowledge presentation at scientific conferences

Fascinating

Expertise in analysis with mouse tumour fashions cell strains or genetic tumour fashions

Good understanding of innate and adaptive immunity

Expertise in circulate cytometry, single cell sequencing, Cas9 based mostly genetic screens, single cell RNA-seq information evaluation utilizing R or Python

About Us

On the Crick, we conduct analysis on the forefront of biomedical analysis. We mix rigour with an open and collaborative tradition, and are outward-looking, reflecting our standing as a partnership of six organisations aiming to pool data, concepts and assets.

We’ve a large analysis portfolio with no divisions or departments, bringing biomedical researchers along with clinicians, bodily scientists and utilized scientists from our pharmaceutical companions.

We intention to draw probably the most proficient researchers and assist them to deal with modern analysis questions. Our science know-how platforms present our researchers with entry to state-of-the-art know-how and experience.

We offer a wonderful studying setting with devoted training programmes in public engagement with science, training and private improvement, and a postdoc coaching programme that prepares scientists for management roles in science.

In case you are curious about making use of for this function, please apply through our .

All provides of employment are topic to profitable safety screening and steady eligibility to work in the UK.

When you require a visa to work within the UK we’ll assist assist your software must you achieve success

Equality, Range & Inclusion

We welcome functions from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender identification, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We notably welcome functions from people who find themselves Minority Ethnic as they’re at present underrepresented within the Crick at this stage.

Range is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We would like the Crick to be a spot the place everybody feels valued and the place range is widely known and seen as a part of the muse for our Institute’s success.

The Crick is dedicated to creating equality of alternative and selling range and inclusivity. All of us share within the duty to actively promote dignity, respect, inclusivity and equal therapy and it’s our intention to make sure that these ideas are mirrored and applied in all methods, insurance policies and practices.

Learn extra on our web site:

Discover out what advantages the Crick has to supply:

For extra info on our nice pay and advantages bundle please click on right here:

Equality, Range & Inclusion:

We welcome functions from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender identification, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We notably welcome functions from people who find themselves Minority Ethnic as they’re at present underrepresented within the Crick at this stage.

Range is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We would like the Crick to be a spot the place everybody feels valued and the place range is widely known and seen as a part of the muse for our Institute’s success.

The Crick is dedicated to creating equality of alternative and selling range and inclusivity. All of us share within the duty to actively promote dignity, respect, inclusivity and equal therapy and it’s our intention to make sure that these ideas are mirrored and applied in all methods, insurance policies and practices.

Learn extra on our web site:

Anticipated wage

Location

London

Job date

Fri, 15 Mar 2024 02:14:11 GMT

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