Postdoctoral Fellow – Hill lab
Francis Crick Institute
Postdoctoral Fellow – Hill labReporting to: Caroline Hill, Head of Developmental Signalling LaboratoryContact time period: It is a full-time, fastened time period [4 years] place on Crick phrases and situations of employment.Wage for this Function: From £41,935 with advantages, topic to expertise and expertiseThe Analysis GroupThe Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate improvement and illness – see . Their work seeks to know how TGF-b household signalling pathways operate usually in early vertebrate improvement and in grownup untransformed cells, and the way these signalling pathways are perturbed in illness, particularly in most cancers and the Marfan-related syndromes. Work within the Hill laboratory exploits the very highly effective mixture of early vertebrate developmental methods (zebrafish embryos), along with quite a lot of mannequin tissue tradition methods (human and mouse ES cell/iPS cell fashions), and mouse most cancers fashions and makes use of a really big selection of methodologies together with developmental and cell biology, most cancers biology, subsequent technology sequencing and computational modelling. The Hill lab encourages artistic and unbiased pondering and promotes glorious coaching and mentoring. The group presently contains ten folks – 5 postdocs, two PhD college students, a medical fellow, a grasp’s pupil and a senior laboratory analysis scientist.For chosen current publications see:The ChallengeCurrent work in my lab has decided that mesoderm and endoderm specification in zebrafish embryos requires the interaction of two signalling pathways, Nodal and Fgf/Erk. We have now proven that the distribution of endodermal progenitors outcomes from a stochastic course of the place sustained Nodal signalling supplies a competency window for the switching of bipotential progenitors to an endodermal destiny. Switching is seemingly stochastic and is inhibited by Fgf/Erk signalling. Cells that don’t swap to the endodermal destiny, differentiate to mesoderm. Thus, we hypothesise that brief home windows of Erk inactivity govern the switching to the endodermal destiny and we’ve got proven that these happen as cells endure mitosis on account of a phenomenon we’re calling mitotic erasure.We now wish to perceive whether or not the same mechanism controls the cell destiny determination between mesoderm and definitive endoderm in people, and if not, how this destiny determination is managed. To undertake this work, I’m in search of a extremely motivated postdoc with confirmed analysis skills and a very good publication file.The mission will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We’ll multiplex our novel Erk biosensor with dwell cell destiny reporters to find whether or not and the way Erk signalling is concerned within the cell destiny determination between definitive endoderm and mesoderm. Moreover, we are going to use multiomics scRNA-seq and scATAC-seq methodology, in addition to complete genome CRISPR screening approaches to realize unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in people.Postdoctoral Fellows on the Crick lead their very own initiatives, contribute to different initiatives on a collaborative foundation (each within the lab and with exterior collaborators) and will information PhD college students of their analysis. The flexibility to work in a crew is crucial.Key expertise and competenciesThe submit holder ought to embody and display our core Crick values:Daring; Imaginative; Open; Dynamic; CollegialImportant
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. * The time limit for purposes is 30 April 2024 at 23:59
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Wed, 27 Mar 2024 23:44:39 GMT
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