Postdoctoral Fellow – Hill lab

Job title:

Postdoctoral Fellow – Hill lab

Firm

Francis Crick Institute

Job description

Postdoctoral Fellow – Hill labReporting to: Caroline Hill, Head of Developmental Signalling LaboratoryContact time period: It is a full-time, fastened time period [4 years] place on Crick phrases and situations of employment.Wage for this Function: From £41,935 with advantages, topic to expertise and expertiseThe Analysis GroupThe Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate improvement and illness – see . Their work seeks to know how TGF-b household signalling pathways operate usually in early vertebrate improvement and in grownup untransformed cells, and the way these signalling pathways are perturbed in illness, particularly in most cancers and the Marfan-related syndromes. Work within the Hill laboratory exploits the very highly effective mixture of early vertebrate developmental methods (zebrafish embryos), along with quite a lot of mannequin tissue tradition methods (human and mouse ES cell/iPS cell fashions), and mouse most cancers fashions and makes use of a really big selection of methodologies together with developmental and cell biology, most cancers biology, subsequent technology sequencing and computational modelling. The Hill lab encourages artistic and unbiased pondering and promotes glorious coaching and mentoring. The group presently contains ten folks – 5 postdocs, two PhD college students, a medical fellow, a grasp’s pupil and a senior laboratory analysis scientist.For chosen current publications see:The ChallengeCurrent work in my lab has decided that mesoderm and endoderm specification in zebrafish embryos requires the interaction of two signalling pathways, Nodal and Fgf/Erk. We have now proven that the distribution of endodermal progenitors outcomes from a stochastic course of the place sustained Nodal signalling supplies a competency window for the switching of bipotential progenitors to an endodermal destiny. Switching is seemingly stochastic and is inhibited by Fgf/Erk signalling. Cells that don’t swap to the endodermal destiny, differentiate to mesoderm. Thus, we hypothesise that brief home windows of Erk inactivity govern the switching to the endodermal destiny and we’ve got proven that these happen as cells endure mitosis on account of a phenomenon we’re calling mitotic erasure.We now wish to perceive whether or not the same mechanism controls the cell destiny determination between mesoderm and definitive endoderm in people, and if not, how this destiny determination is managed. To undertake this work, I’m in search of a extremely motivated postdoc with confirmed analysis skills and a very good publication file.The mission will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We’ll multiplex our novel Erk biosensor with dwell cell destiny reporters to find whether or not and the way Erk signalling is concerned within the cell destiny determination between definitive endoderm and mesoderm. Moreover, we are going to use multiomics scRNA-seq and scATAC-seq methodology, in addition to complete genome CRISPR screening approaches to realize unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in people.Postdoctoral Fellows on the Crick lead their very own initiatives, contribute to different initiatives on a collaborative foundation (each within the lab and with exterior collaborators) and will information PhD college students of their analysis. The flexibility to work in a crew is crucial.Key expertise and competenciesThe submit holder ought to embody and display our core Crick values:Daring; Imaginative; Open; Dynamic; CollegialImportant

• PhD in a related organic science
• Good information and arms on expertise of working with embryonic stem cells
• Technical experience in differentiating embryonic stem cells to completely different tissue varieties
• Technical experience in dwell imaging
• Monitor file of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Proof of knowledge presentation at scientific conferences
• Sturdy organisational expertise and thorough record-keeping
• Skill to work independently and in addition in a crew

Fascinating

• Expertise in sign transduction analysis
• Expertise in ‘omics methods and bioinformatic evaluation

About UsOn the Crick, we conduct analysis on the forefront of biomedical analysis. We mix rigour with an open and collaborative tradition, and are outward-looking, reflecting our standing as a partnership of six organisations aiming to pool information, concepts and sources.We have now a large analysis portfolio with no divisions or departments, bringing biomedical researchers along with clinicians, bodily scientists, and utilized scientists from our pharmaceutical companions.We intention to draw essentially the most proficient researchers and help them to deal with modern analysis questions. Our science expertise platforms present our researchers with entry to state-of-the-art expertise and experience.We offer a wonderful studying surroundings with devoted schooling programmes in public engagement with science, schooling and private improvement, and a postdoc coaching programme that prepares scientists for management roles in science.

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Discover out what advantages the Crick has to supply:For extra data on our nice pay and advantages bundle please click on right here:Equality, Range & Inclusion:We welcome purposes from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender identification, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We significantly welcome purposes from people who find themselves Minority Ethnic as they’re presently underrepresented within the Crick at this stage.Range is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We wish the Crick to be a spot the place everybody feels valued and the place variety is widely known and seen as a part of the inspiration for our Institute’s success.The Crick is dedicated to creating equality of alternative and selling variety and inclusivity. All of us share within the duty to actively promote dignity, respect, inclusivity and equal therapy and it’s our intention to make sure that these ideas are mirrored and carried out in all methods, insurance policies and practices.Learn extra on our web site:

Anticipated wage

Location

London

Job date

Wed, 27 Mar 2024 23:44:39 GMT

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