Postdoctoral Fellow in Scientific Machine Learning – Fröhlich lab

Job title:

Postdoctoral Fellow in Scientific Machine Studying – Fröhlich lab

Firm

Francis Crick Institute

Job description

Postdoctoral Fellow in Scientific Machine Studying – Fröhlich labReporting to: Fabian Fröhlich, Group ChiefContact time period: This can be a full-time, fastened time period (4 years) place on Crick phrases and circumstances of employment.Time limit and time: open till crammedThe Analysis GroupThe Fröhlich lab builds computational fashions to unravel the regulatory ideas underlying the dynamics of intracellular signalling. We construct these fashions by mixing methods from mathematical modelling and machine studying. Extra particulars in regards to the group and our analysis pursuits will be discovered on the lab’s webpageThe profitable candidate will be a part of a rising, multi-disciplinary group of scientist with the chance to contribute personal concepts and assist form the analysis profile of the lab. At present, there may be one PhD scholar and one Postdoc within the group, who’ve backgrounds in structural biology, techniques biology, electrical engineering, and chemical nanotechnology. Analysis initiatives will likely be supported by a vibrant, multi-disciplinary scientific group on the Crick, with ample alternatives for inside and exterior collaborations. Furthermore, the candidate may have entry to state-of-the-art core services on the Crick, together with the Excessive-Efficiency-Computing platform, in addition to structured profession growth and wealthy networking alternatives.The FunctionA number of analysis avenues are pursued inside our laboratory, providing the profitable candidate the autonomy to develop and lead their very own unbiased analysis initiatives aligned with the lab’s focus. Potential initiatives embody:

• Unravelling emergent dynamical legal guidelines from complicated mathematical fashions of protein-protein interactions. Using symbolic regression methods on simulated information allows the extraction of simplified fee legal guidelines, integral for developing fashions of multi-component signalling pathways. These fashions might then be used examine sign transduction heterogeneity ensuing from fluctuations in protein ranges or to design artificial multicomponent signalling cascades de novo.
• Crafting dynamic, multi-pathway sign transduction fashions by integrating prior information networks (PKNs) with phosphoproteomic information. Remodeling PKNs, which consolidate information graphs, pathway databases, and protein construction info, into simulatable fashions permits for validation towards dynamic multi-condition proteomics datasets. The first goal is to discern the regulatory ‘grammar’ governing phosphorylation dynamics, elucidating molecular mechanisms or mobile processes that drive signalling dynamics.
• Deciphering cell cycle dynamics utilizing pseudo-time embeddings derived from snapshot mass cytometry information. Leveraging low-dimensional embeddings to temporally order unsynchronized cell populations primarily based on cell cycle marker expression facilitates the training of dynamic fashions from static snapshot information. Leveraging mass cytometry datasets spanning various experimental circumstances – together with progress issue stimulation, genetic modifications, and small molecule drug interventions – goals to unveil the dependency of cell cycle dynamics on upstream signalling.

The submit holder will likely be chargeable for:

• Main and creating particular analysis initiatives
• Creating and sustaining computational instruments
• Making use of strategies to organic information and decoding outcomes
• Collaborating with nationwide and worldwide companions
• Presenting work at lab conferences in addition to nationwide and worldwide conferences
• Publishing scientific outcomes
• Aiding in coaching graduate college students and different members of the laboratory

Key expertise and competenciesThe submit holder ought to embody and reveal our core Crick values:Daring; Open; Collegial, along with the next:Important

• PhD in a related area or within the ultimate phases of PhD submission
• Good information and expertise in coding (Python/Julia/C or comparable languages)
• Technical experience in mathematical modelling and/or machine studying
• An curiosity in making use of computational strategies to organic issues
• A demonstrated capability to generate and pursue unbiased analysis concepts
• Wonderful communication expertise, written and verbal as evidenced by publications, preprints and/or convention shows
• Cross-disciplinary mindset, collaborative angle, and teamwork expertise
• Dedication to reproducible analysis and open science
• A canopy letter that’s tailor-made to the lab and the place

Fascinating

• Foundational information in Cell Biology, Biochemistry and/or Programs Biology
• Foundational information in Arithmetic, Physics, Statistics and/or Information Science
• Background in numerical strategies for optimization and fixing differential equation fashions
• Familiarity with trendy software program growth practices and high-performance computing
• Good command of a machine studying framework (jax/pytorch or comparable)
• Expertise working in interdisciplinary environments

Notice that the perfect candidate is just not anticipated to have all fascinating expertise, however this itemizing is meant to present you some steerage of what experiences to spotlight in your cowl letter.About UsOn the Crick, we conduct analysis on the forefront of biomedical analysis. We mix rigour with an open and collaborative tradition, and are outward-looking, reflecting our standing as a partnership of six organisations aiming to pool information, concepts and assets.We’ve got a large analysis portfolio with no divisions or departments, bringing biomedical researchers along with clinicians, bodily scientists and utilized scientists from our pharmaceutical companions.We intention to draw essentially the most proficient researchers and help them to deal with progressive analysis questions. Our science know-how platforms present our researchers with entry to state-of-the-art know-how and experience.We offer a wonderful studying setting with devoted schooling programmes in public engagement with science, schooling and private growth, and a postdoc coaching programme that prepares scientists for management roles in science.

• If you’re excited about making use of for this position, please apply through our

. * All gives of employment are topic to profitable safety screening and steady eligibility to work in the UK.

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Equality, Range & InclusionWe welcome purposes from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender id, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We significantly welcome purposes from people who find themselves Minority Ethnic as they’re at present underrepresented within the Crick at this stage.Range is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We would like the Crick to be a spot the place everybody feels valued and the place range is widely known and seen as a part of the inspiration for our Institute’s success.The Crick is dedicated to creating equality of alternative and selling range and inclusivity. All of us share within the accountability to actively promote dignity, respect, inclusivity and equal therapy and it’s our intention to make sure that these ideas are mirrored and applied in all methods, insurance policies and practices.Discover out what advantages the Crick has to supply:For extra info on our nice pay and advantages package deal please click on right here:

Anticipated wage

Location

London

Job date

Tue, 19 Mar 2024 23:04:30 GMT

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