Postdoctoral Fellow – Metabolic Disease Research

City of Hope

Thanks in your curiosity.  Please be aware, the aim of this posting is to recruit for on-going and future positions.

About Metropolis of Hope

Metropolis of Hope is an impartial analysis and therapy heart for diabetes, most cancers and different life-threatening ailments. Bringing collectively the perfect in bench-to bedside analysis, Metropolis of Hope’s Arthur Riggs Diabetes & Metabolism Analysis Institute (AR-DMRI) is among the world’s most complete diabetes analysis packages. 

Metropolis of Hope has an extended and spectacular historical past of groundbreaking discoveries within the subject of diabetes spanning greater than 5 a long time since Rachmiel Levine, M.D., who found the function of insulin in glucose transport, launched diabetes analysis at Metropolis of Hope within the Seventies. The Institute is known as for Arthur D. Riggs, Ph.D., one other pioneer within the subject well-known for his work on synthesizing the primary man-made gene and utilizing artificial genes to provide human insulin, now the usual of take care of individuals with diabetes worldwide. The AR-DMRI is headed by Debbie Thurmond, Ph.D., a famend analysis scientist, professor and founding chair of the Division of Molecular & Mobile Endocrinology.  

Metropolis of Hope can be dwelling to seminal Nationwide Institute of Diabetes and Digestive and Kidney Ailments (NIDDK) packages, such because the Human Islet Analysis Community (HIRN) and the Built-in Islet Distribution Program (IIDP), that lead the sphere of diabetes in diabetes analysis and translational potential. 

Metropolis of Hope is situated in Los Angeles, California, with neighborhood clinics all through Southern California. It just lately acquired Most cancers Remedy Facilities of America, extending its nationwide attain. One among solely 53 NCI-designated complete most cancers facilities within the nation, it has been ranked as one in every of “America’s Greatest Hospitals” in most cancers by U.S. Information & World Report for over 15 years. Based in 1913, Metropolis of Hope is a pioneer within the fields of immunotherapy and medical islet cell transplantation for diabetes, bone marrow transplantation and quite a few breakthrough most cancers medication, many primarily based on know-how developed on the establishment. 

Metropolis of Hope’s dedication to Range, Fairness and Inclusion

We consider variety, fairness and inclusion is essential in serving our mission to supply compassionate affected person care, drive revolutionary discovery, and advance important schooling centered on eliminating most cancers and diabetes in all of our communities.  Our dedication to Range, Fairness and Inclusion ensures we convey the total vary of abilities, views, cultural backgrounds and experiences to our work — and that our groups align with the individuals we serve with a view to construct belief and understanding.  We’re devoted to fostering a neighborhood that embraces variety – in concepts, backgrounds and views; that is mirrored in our work and represented in our individuals.

Place Abstract

A Postdoctoral Fellow place is instantly out there within the laboratory of Dr. Ke Ma, Affiliate Professor, on the Arthur Riggs Diabetes and Metabolism Analysis Institute inside Beckman Analysis Institute of Metropolis of Hope, CA. 

The Ma lab applies state-of-the-art circadian biology, molecular and mobile biology approaches to diabetes and weight problems analysis, with an final purpose to unravel circadian etiologies underlying the present epidemics of metabolic ailments for focused therapeutic interventions. We’ve got a novel analysis program in deciphering the mechanistic underpinnings of circadian clock management in metabolic tissue growth, progress and purposeful capability, specializing in skeletal muscle and adipose tissue biology. Current initiatives increase into drug screening platforms to determine clock-targeting small molecules for metabolic illness functions.  

We’re searching for a extremely motivated postdoctoral fellow with sturdy enthusiasm for metabolic illness or stem cell analysis to check molecular signaling mechanisms underlying circadian clock operate in skeletal muscle and adipose tissue. Candidates with sturdy coaching in biochemistry, cell biology and molecular biology strategies with in vivo mouse mannequin analysis background are most well-liked, and prior expertise with circadian biology or metabolic analysis is a plus. Using biochemical and molecular biology approaches mixed with genetic animal fashions, particular analysis instructions within the lab embrace: 1) genetic and epigenetic signaling networks mediating circadian clock nutrient-sensing operate in adipose tissue and skeletal muscle; 2) circadian clock regulation of skeletal muscle progress and metabolism; 3) novel signaling mechanisms in core circadian clock regulation, and 4) creating small molecule clock-modulators for metabolic illness remedy.

Primary schooling, expertise and abilities required for consideration:

·         PhD in Molecular, Mobile or Developmental Biology with a powerful curiosity to pursue metabolic illness analysis

·         Proficiency with biochemical strategies, molecular biology abilities and cell tradition techniques.

·         Expertise with in vivo animal mannequin analysis, biochemistry, cell biology and animal physiology most well-liked.

·         Expertise with metabolic, epigenetics and stem cell analysis together with bioinformatics evaluation a plus.

·         Extremely motivated with sturdy curiosity in metabolic illness analysis.

·         Sturdy work ethic and skill to work successfully in a crew. 

Further Data:

As a situation of employment, Metropolis of Hope requires employees to adjust to all state and federal vaccination mandates.

·         For extra data on Dr. Ma’s lab please go to right here:

·         For a listing of publications please go to right here:

·         To use, please present your present CV, a quick analysis assertion describing your background, experiences and profession targets, and a listing of three references to [email protected].

The estimated pay scale represents the everyday [salary/hourly] vary Metropolis of Hope moderately expects to pay for this place, with presents decided primarily based on a number of elements which can embrace, however not be restricted to, the candidate’s expertise, experience, abilities, schooling, job scope, coaching, inside fairness, geography/market, and so forth.  This pay scale is topic to vary on occasion.

Metropolis of Hope is dedicated to creating a various surroundings and is proud to be an equal alternative employer.  All certified candidates will obtain consideration for employment with out regard to race, faith, shade, nationwide origin, intercourse, sexual orientation, gender id, age, standing as a protected veteran, or standing as a professional particular person with incapacity.

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