Postdoctoral Fellow – NW Goehring lab

Job title:

Postdoctoral Fellow – NW Goehring lab

Company

Francis Crick Institute

Job description

Postdoctoral Fellow – NW Goehring labReporting to: Nathan Goehring, Senior Group LeaderContact term: This is a full-time, fixed term [4 year] position on Crick terms and conditions of employment.Please note this is a rolling advert with no specific closing date. Applications will be considered as they arrive and will close once the position is filled.The Research GroupWork in the Goehring lab aims to understand how cell polarity is established by molecular networks that transduce symmetry-breaking cues into stable molecular asymmetries. Our work focuses on a conserved polarity network defined by the PAR (PAR-titioning defective) proteins, which underlie polarity in diverse contexts, including defining epithelial architecture and function, driving asymmetric division of stem cells, and specifying cell fate of embryonic blastomeres.Using the C. elegans embryo as a model, our interdisciplinary team combines genetics, quantitative imaging, in vivo biophysics, and mathematical modelling to link system-level properties of the PAR network to molecular behaviours, thereby providing a multi-scale model for how PAR proteins polarize cells in response to developmental cues and ultimately how polarized patterns are read out by the downstream pathways that define a cell’s functional polarity. For more detail, please see our .Position SummaryWe aim to recruit a talented and motivated Postdoctoral Training Fellow to join our group. Postdoctoral Training Fellows are expected to lead their own projects, generate and pursue independent research ideas, mentor junior researchers, and contribute to other projects on a collaborative basis (both in the lab and with external collaborators).Some examples of current projects include:

• Modeling and manipulating PAR network feedback circuits
• Quantitative exploration of kinase-substrate interactions in polarity networks
• Coupling of mechanical(cytoskeletal) and biochemical networks during cell polarization
• Cell cycle control of cell polarity and fate specification pathways
• Canalization of developmental variability during embryogenesis
• Mechanisms for encoding cellular memory

This position offers substantial freedom regarding research direction. The specific project will be developed together with the successful candidate, taking into consideration their specific interests and experience. We welcome applications from diverse backgrounds who can bring new ideas, tools, and/or perspectives to the group.Note this is a core-funded position, though successful candidates will be encouraged to pursue external fellowship support.Potential applicants are encouraged to submit informal inquiries to . Please include a clear statement of why you are interested in the lab, what types of projects/questions you would like to pursue, and how you see yourself contributing to our group.Key experience and competenciesThe post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:Essential

• PhD (awarded or expected) in Cell and Developmental Biology, Biochemistry, Biophysics or similar. Applicants from Physics, Computer Science or Engineering backgrounds seeking to expand their skills in the context of a combined wet/dry project are also welcome to apply.
• A demonstrated ability to generate and pursue independent research ideas
• A demonstrated ability to work as part of an interdisciplinary team
• Willingness to mentor junior members of the laboratory
• Strong communication and presentation skills
• Strong organisational and record-keeping skills
• Track record of scientific scholarship, evidenced by preprints, publications or submitted manuscripts in refereed journals

About UsAt the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

• If you are interested in applying for this role, please apply via our

. * The closing date for applications is 2024 at 23:59

• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
• If you require a visa to work in the UK we will help support your application should you be successful

Equality, Diversity & InclusionWe welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:Find out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

Location

London

Job date

Wed, 25 Dec 2024 23:28:16 GMT

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