Postdoctoral Fellow – Organic Chemistry

Job title:

Postdoctoral Fellow – Natural Chemistry

Firm

College of Alberta

Job description

DescriptionThis place has an preliminary appointment of 1 yr and presents a advantages package deal discovered at .Location – North Campus Edmonton. This position is in-person.Working for the College of AlbertaThe College of Alberta acknowledges that we’re positioned on Treaty 6 territory, and respects the histories, languages and cultures of First Nations, Métis, Inuit and all First Peoples of Canada, whose presence continues to counterpoint our vibrant group.The College of Alberta is teeming with change makers, group builders, and world shapers who lead with function every day. We’re dwelling to greater than 40,000 college students in 200+ undergraduate and 500+ graduate applications, over 13,000 school and employees, 260,000 alumni worldwide and have been acknowledged as certainly one of Canada’s Greenest Employers for over a decade.Your work can have a significant affect on a captivating cross part of people-from our college students and stakeholders, to our famend researchers and innovators who’re fairly actually curing ailments, making discoveries and producing options that make the world more healthy, safer, stronger, and extra simply.Working for the Division/SchoolDr. David Wishart is a Distinguished College Professor throughout the Division of Organic Sciences on the College of Alberta. He’s a extremely revered scientist and operates one of many UofA’s most extensively geared up and superior laboratories. His state-of-the-art analysis amenities are housed inside each the Division of Organic Sciences and the Centennial Centre for Interdisciplinary Sciences on the College of Alberta North campus. Dr. Wishart’s laboratories include greater than $10 million in cutting-edge analytical gear together with greater than a half dozen high-end mass spectrometers and a totally geared up 700 MHz NMR spectrometer. Dr. Wishart’s analysis spans a various spectrum of analysis fields, starting from precision well being, most cancers (particularly lung and breast), infectious ailments (with a give attention to COVID-19), neurological ailments (together with Alzheimer’s and ALS), kidney ailments, animal/livestock well being, forestry analysis, microbiome analysis, meals chemistry, structural biology, transportable sensor techniques, and metabolomics expertise improvement. He has energetic collaborations with greater than 30 scientists around the globe. For additional particulars about Dr. Wishart and his laboratory, please go to The Metabolomics Innovation Centre (TMIC) web site at and the Wishart Node TMIC web site at .PlaceWe’re looking for a extremely motivated and expert postdoctoral fellow in natural chemistry to hitch our dynamic analysis group. Underneath the steerage of the Principal Investigator (PI), you’ll play a pivotal position as an artificial chemist, contributing to the cutting-edge discipline of metabolomics. Your main accountability will probably be to synthesize small natural molecules, serving as novel reference requirements important for advancing metabolomic analysis. This position presents a singular alternative to actively interact in modern scientific endeavours, collaborate with famend consultants, and make important contributions to our understanding of metabolomics.Duties

• Finishing up synthesis of small natural molecules as novel reference requirements used for metabolomic analysis. The related compounds are usually biomarkers and will probably be used to arrange commonplace options for LC-MS analyses of biofluids.
• Performing synthesis of isotopically labelled derivatizing reagents used for Isotope Coded Derivatization (ICD).
• Designing and synthesizing novel small molecule ICD reagents helpful for LC-MS and GC-MS analyses.
• Purifying synthesized compounds utilizing numerous strategies comparable to flash chromatography, preparative TLC or HPLC, to attain the specified excessive purity degree.
• Optimizing the artificial situations and scaling up of the reagents as required.
• Optimizing of the response situations for the derivatization of the metabolites utilizing the synthesized reagents.
• Synthesizing libraries of derivatized metabolites together with amino acids which might be instantly used as LC-MS requirements for quantification.
• Analyzing the synthesized compounds by LC-MS, NMR and different platforms as wanted for characterization in addition to for quantification.
• Presentation of analysis ends in laboratory conferences, seminars, and scientific conferences
• Preparation of analysis papers, shows, and publications beneath the route of the belief holder.
• Performs literature critiques to find out possible experimental choices for the event of strategies to synthesize compounds of curiosity.
• Coordinates gear and lab actions with different laboratory and undertaking employees to facilitate undertaking progress.
• Works with a excessive diploma of independence following a analysis plan accredited by the Pl.
• Writes first draft of manuscripts.
• Prepares abstracts for convention conferences and presents these analysis findings at conferences.

Minimal {Qualifications}

• PhD in artificial natural chemistry.
• Clear understanding of the scope and position of natural chemistry in metabolomic analysis.
• Expertise in dealing with hazardous reagents together with isotopically labelled compounds.
• Expertise in synthesis of small molecules and their purification utilizing liquid chromatography/preparative HPLC/preparative TLC. In-depth data and expertise in purification strategies is a should because the synthesized compounds are required to be of excessive purity which will probably be used for delicate LC-MS analyses required for metabolomic analysis.
• Thorough data of performing milligram scale reactions for optimization in addition to scale as much as the multigram stage is required.
• Means to work independently on advanced analysis tasks and report and publish the scientific outcomes beneath direct supervision of belief holder.
• Means to work on a number of tasks.
• Sustaining a protected and collegial working atmosphere following Customary Working Procedures for security together with WHIMIS pointers.

Most well-liked {Qualifications}

• Expertise in buying NMR and Mass spectral knowledge for characterization of the compounds is an asset.

The right way to ApplyTo have your utility thought-about, please choose the Apply On-line icon under and submit the next:

• Resume and Cowl letter in a single doc
• Three references

All certified candidates are inspired to use; nevertheless, Canadians and everlasting residents will probably be given precedence. If appropriate Canadian residents or everlasting residents can’t be discovered, different people will probably be thought-about.We thank all candidates for his or her curiosity; nevertheless, solely these people chosen for an interview will probably be contacted.The College of Alberta is dedicated to an equitable, various, and inclusive workforce. We welcome purposes from all certified individuals. We encourage ladies; First Nations, Métis and Inuit individuals; members of seen minority teams; individuals with disabilities; individuals of any sexual orientation or gender identification and expression; and all those that could contribute to the additional diversification of concepts and the College to use.

Anticipated wage

Location

Edmonton, AB

Job date

Wed, 27 Mar 2024 02:17:55 GMT

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