Location: The Francis Crick Institute, Midland Road, London
Pontus Skoglund’s Ancient Genomics Lab at the Francis Crick Institute in London is looking for a postdoctoral fellow interested in proteomic approaches to human origins. The Skoglund Ancient Genomics lab (www.skoglundlab.org ) is a dynamic team with backgrounds in computational biology, molecular biology and archaeology, with state-of-the-art computational infrastructure and an ancient DNA clean room facility. The Francis Crick Institute (www.crick.ac.uk ) is the largest biomedical institute under one roof in Europe. The Institute is located next to King’s Cross in central London, with excellent transport links to greater London and Cambridge.
Ancient genome sequencing has revolutionised our understanding of the evolutionary history of modern humans and close relatives such as Neandertals. However, in most environments DNA may only be retrieved from a few thousand years ago. In contrast, proteins degrade more slowly than DNA, and may thus allow insights from deeper time. However, the number of evolutionarily informative variants is lower in ancient proteomic data, and authentication methods for ancient proteomics are in their infancy compared to methods for ancient DNA.
This postdoc fellow will join Pontus Skoglund and the Crick Ancient Genomics laboratory in applying and developing proteomic approaches to extend our understanding of human evolution. The work will include improving and developing methods for bioinformatic retrieval, authentication, and reconstruction of ancient protein sequences from extinct populations in collaboration with proteomics experts at the Francis Crick Institute and international collaborators. Then adapting population genetic and phylogenetic approaches (f-statistics & admixture graphs), and applying the methods to data from fossil material supported by the ancient DNA facility.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 15.07.2023
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
View or Apply
To help us track our recruitment effort, please indicate in your cover/motivation letter where (globalvacancies.org) you saw this job posting.