Postdoctoral Fellow – Ultanir Lab

Location: The Francis Crick Institute, Midland Street, London

Quick abstract

An thrilling alternative for a motivated postdoctoral scientist to affix Kinases and Mind Growth laboratory https://www.crick.ac.uk/analysis/labs/sila-ultanir on the Francis Crick Institute, London, UK. The postdoctoral place shall be in collaboration with Dr Florencia Iacaruso laboratory https://www.crick.ac.uk/analysis/labs/flor-iacaruso ,  who makes use of state-of-the-art in vivo mind recordings and optogenetics strategies in awake-behaving mice to analyse visible perform.  

Dr Ultanir’s laboratory focuses on the position of protein kinases in neuronal improvement and performance. Kinases regulate quite a few mobile processes by phosphorylating their substrates and altering their perform. CDKL5 is a mind enriched serine/threonine kinase. Lack of perform mutations of CDKL5 trigger a extreme neurodevelopmental dysfunction with early-onset seizures, termed CDKL5 deficiency dysfunction (CDD). Our lab’s purpose is to grasp the roles of CDKL5 within the mind and to disclose how lack of CDKL5 results in neuronal pathology. 

The undertaking goals to disclose mobile and circuitry degree features of CDKL5 in visible improvement. On this collaborative undertaking, the postdoctoral fellow will use CDKL5 knockout mice, phosphomutant mouse fashions of CDKL5 substrates and different genetic interventions to find out crucial signalling pathways for visible cortex improvement.

Postdoctoral Fellow will lead their very own tasks, are anticipated to contribute to different tasks on a collaborative foundation (each within the lab and with exterior collaborators) and assist practice PhD college students. 

Key expertise and competencies

The put up holder ought to embody and exhibit our core Crick values:

Daring; Open; Collegial

Important

• PhD in neuroscience, biology or a associated self-discipline or within the closing levels of PhD submission
• Good information and expertise in craniotomy, in vivo mouse mind recordings
• Monitor document of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Proof of information presentation at scientific conferences 

About us

The Francis Crick Institute is a biomedical discovery institute devoted to understanding the elemental biology underlying well being and illness. Its work helps to grasp why illness develops and to translate discoveries into new methods to stop, diagnose and deal with diseases equivalent to most cancers, coronary heart illness, stroke, infections, and neurodegenerative ailments.

An impartial organisation, its founding companions are the Medical Analysis Council (MRC), Most cancers Analysis UK, Wellcome, UCL (College Faculty London), Imperial Faculty London and King’s Faculty London.

The Crick was shaped in 2015, and in 2016 it moved into a brand new state-of-the-art constructing in central London which brings collectively 1500 scientists and help workers working collaboratively throughout disciplines, making it the most important biomedical analysis facility underneath in a single constructing in Europe.

The Francis Crick Institute shall be world-class with a powerful nationwide position. Its distinctive imaginative and prescient for excellence contains commitments to collaboration; growing rising expertise and exporting it the remainder of the UK; public engagement; and serving to flip discoveries into remedies as rapidly as attainable to enhance lives and strengthen the economic system. 

• In case you are all in favour of making use of for this position, please apply through our web site.
• The deadline for purposes is 27.10.23
• All gives of employment are topic to profitable safety screening and steady eligibility to work in the UK.