Postdoctoral Project Research Scientist

Job title:

Postdoctoral Project Research Scientist

Company

Francis Crick Institute

Job description

Postdoctoral Project Research ScientistReports to:Erik SahaiContact term:This is a full-time, fixed term (2 year) position on Crick terms and conditions of employment.Project summaryThe Postdoctoral Project Research Scientist role is to provide support to interlinked projects within the Sahai group. We are seeking to understand the tumour microenvironment of metastatic disease and how it might be targeted for therapeutic benefit. Particular attention will be paid to cancer-associated fibroblasts the extracellular matrix. The project will involve the generation of lung and liver metastasis models, and the subsequent transcriptomic and spatial analysis of the tissue. Perturbations to the tumour systems are likely to include radioligand therapy, radiotherapy, and immune-modulating agents. Key outputs will be the response of models to therapy and linked quantitative information about the spatial organisation of the tissue.The Research GroupDr Sahai’s laboratory focuses on how the tumour microenvironment influences the spread of cancer and how it responds to therapies. Details of research projects currently being undertaken can be seen at:The research aims to understand the stromal microenvironment of metastases and how it can be targeted. In this project, some of the specific aims could include but not be limited to:

• Spatial analysis of the tumour microenvironment using highly multiplexed immunostaining

Analysis of responses to targeted, radiotherapy, and immunotherapiesEstablishment and analysis of co-culture models of the tumour microenvironmentPostdoctoral Project Research Scientists are expected contribute to between 1 and 2 projects at any one time on a collaborative basis (both in the lab and with external collaborators). They are expected to be able to plan, execute, and interpret experiments and steer the long-term direction of projects in cooperation with the group leader. The ability to work in a team and communicate with other teams is essential.Key responsibilitiesThese include but are not limited to:Collaborating with other lab members on research projects.Providing experimental or technical support to other lab members.Providing technical expertise for the development, refinement and troubleshooting of relevant methodologies.Design and execute experiments using transient- and viral-based expression systems to modulate the activity/expression of target proteinsParticipating in academic activities, including group meetings and journal clubs, seminars,Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring, and routine maintenance of laboratory equipment.Key experience and competenciesThe post holder should embody and demonstrate our core Crick values: bold, open, and collegial, in addition to the following:EssentialPhD in cell or cancer biology, or in the final stages of PhD submission.Good knowledge and experience in cancer biologyTechnical expertise in cell culture, immunostaining of cells or tissues, and fluorescence microscopyTrack record of contribution to papers as evidenced by publications or submitted manuscripts in referred journalsEvidence of data presentation at scientific meetingsExperience of experimental designAbility to work independently and also capable of working effectively in a multi-disciplinary teamDesirableExperience in research with model biological systemExperience in molecular biology and/or highly multiplexed immunostainingExperience in design and delivery of pre-clinical cancer modelsExperience in quantitative analysis of experimental data using R, Matlab, or similarHas a desire to work in pre-clinical cancer models, respects and has empathy towards the care and use of animals in sciencePossesses good observational, attention to detail, and record keeping skillsWorks in a flexible, but organised manner, to meet objectives/deadlinesFind out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

Location

London

Job date

Thu, 30 May 2024 22:41:34 GMT

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